Article (Scientific journals)
Adrenomedullin refines mortality prediction by the BODE index in COPD - The "BODE-A" index.
Stolz, Daiana; Kostikas, Kostantinos; Blasi, Francesco et al.
2014In European Respiratory Journal
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Keywords :
Biomarker; COPD; PROMISE-COPD study; multidimensional assessment; outcome
Abstract :
[en] The BODE index is well-validated for mortality prediction in COPD. Concentrations of plasma proadrenomedullin, a surrogate for mature adrenomedullin, independently predicted 2-year mortality among inpatients with COPD exacerbation.We compared accuracy of initial proadrenomedullin level, BODE, and BODE components, alone or combined, in predicting 1-year or 2-year all-cause mortality in a multicenter, multinational observational cohort with stable, moderate to very severe COPD.Proadrenomedullin was significantly associated (P<0.001) with 1-year mortality (4.7%) and 2-year mortality (7.8%), and comparably predictive to BODE regarding both (C statistics: 0.691 vs. 0.745, 0.635 vs. 0.679). Relative to using BODE alone, adding proadrenomedullin significantly improved 1-year and 2-year mortality prognostication (C statistics: 0.750, 0.818; both P<0.001). Proadrenomedullin plus BOD was more predictive than was the original BODE including 6-minute-walk distance. In multivariable analysis, proadrenomedullin (LR X2 13.0, P<0.001), body mass index (8.5, P=0.004), and 6-minute-walk distance (7.5, P=0.006), but not modified MMRC dyspnoea score (2.2, P=0.14) or FEV1 % predicted (0.3, P=0.60), independently foretold 2-year survival.Proadrenomedullin plus BODE better predicts mortality in COPD patients than does BODE alone; proadrenomedullin may substitute for 6-minute-walk distance in BODE when 6-minute-walk testing is unavailable.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Stolz, Daiana
Kostikas, Kostantinos
Blasi, Francesco
Boersma, Wim
Milenkovic, Branislava
Lacoma, Alicia
LOUIS, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Aerts, Joachim G.
Welte, Tobias
Torres, Antoni
Rohde, Gernot G. U.
Boeck, Lucas
Rakic, Janko
Scherr, Andreas
Hertel, Sabine
Giersdorf, Sven
Tamm, Michael
More authors (7 more) Less
Language :
English
Title :
Adrenomedullin refines mortality prediction by the BODE index in COPD - The "BODE-A" index.
Publication date :
February 2014
Journal title :
European Respiratory Journal
ISSN :
0903-1936
eISSN :
1399-3003
Publisher :
European Respiratory Society, Lausanne, Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 May 2014

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