[en] In Crohn's disease, the activity of the disease is difficult to evaluate and the evolution of the disease is difficult to predict. The soluble interleukin-2 receptor serum level has been reported to correlate with clinical activity of the disease and with mucosal immune activation. We compared serum soluble interleukin-2 receptor to classical inflammatory markers and other immune parameters in the assessment of clinical disease activity and prediction of relapse in patients with Crohn's disease. Soluble interleukin-2 receptor serum levels correlated well with the Crohn's disease activity index, and multivariate analysis showed that this correlation was independent of the other inflammatory and immune markers. The correlation was not greater, However, than that between some inflammatory markers, such as ESR, and Crohn's disease activity index. Longitudinal follow-up showed that a high soluble interleukin-2 receptor serum level was highly predictive of relapse. Multivariate analysis showed that the soluble interleukin-2 recepteur serum level was complementary to other inflammatory and clinical markers in the prediction of relapse of disease. We conclude that soluble interleukin-2 receptor is of use in monitoring Crohn's disease, particularly in prediction of relapse.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Louis, Edouard ; Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
Belaiche, Jacques ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Van Kemseke, Catherine ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Schaaf-Lafontaine, Nicole ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Mahieu, P.
Mary, J. Y.
Language :
English
Title :
Soluble Interleukin-2 Receptor in Crohn's Disease. Assessment of Disease Activity and Prediction of Relapse
Publication date :
August 1995
Journal title :
Digestive Diseases and Sciences
ISSN :
0163-2116
eISSN :
1573-2568
Publisher :
Kluwer Academic/Plenum Publishers, United States - New York
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Strober W., James S.P. (1986) The immunologic basis of inflammatory bowel disease. J Clin Immunol 6:415-432.
Campbell C.A., Walker-Smith J.A., Hindocha P. (1982) Acute phase proteins in chronic inflammatory bowel disease in childhood. J Pediatr Gastroenterol Nutr 1:193-200.
.
Willia A.J.K., Symons J.A., Watchet K., Duff G.W. (1992) Soluble interleukin-2 receptor and disease activity in Crohn's disease. J Autoimmun 5:251-259.
Andre C., Descos I., Vignal J., Gillon J. (1983) C-reactive protein as predictor of relapse in asymptomatic patients with Crohn's disease. Scott Med J 28:26-29.
Brignola C., Campieri M., Bazzocchi G., Farruggia P., Tragnone A., Lanfranchi G.A. (1986) A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease. Gastroenterology 91:1490-1494.
Brignola C., Iannone P., Belloli C., De Simone G., Bassein L., Gionchetti P., Belluzzi A., Campieri M., Barbara L. (1994) Prediction of relapse in patients with crohn's disease in remission: a simplified index using laboratory tests, enhanced by clinical characteristics. Eur J Gastroenterol Hepatol 6:955-961.
Matsuura T., West G.A., Klein J.S., Ferraris L., Fiocchi C. (1992) Soluble interleukin 2 and CD8 and CD4, receptors in inflammatory bowel disease. Gastroenterology 102:2006-2014.
Mahida Y.R., Gallagher A., Kurlak L., Hawkey C.J. (1990) Plasma and tissue interleukin-2 receptor levels in inflammatory bowel disease. Clin Exp Immunol 82:75-80.
Brynskov J., Tvede N. (1990) Plasma interleukin-2 and a soluble/shed interleukin-2 receptor in serum of patients with Crohn's disease. Effect of cyclosporin. Gut 31:795-799.
Mueller C., Knoflach P., Zielinski C.C. (1990) T-cell activation in Crohn's disease. Increased levels of soluble interleukin-2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells. Gastroenterology 98:639-646.
Crabtree J.E., Juby L.D., Heatley R.V., Lobo A.J., Bullimore D.W., Axon A.T.R. (1990) Soluble interleukin-2 receptor in Crohn's disease: relation of serum concentrations to disease activity. Gut 31:1033-1036.
Readler A., Fraenkel S., Klose G., Seyfarth K., Thiele H.G. (1985) Involvement of the immune system in the pathogenesis of Crohn's disease. Expression of the T9 antigen on peripheral immunocytes correlates with the severity of the disease. Gastroenterology 88:978-983.
Rutgeerts P., Geboes K., Vantrappen G., Beyls J., Kerremans R., Hiele M. (1990) Predictability of the postoperative course of Crohn's disease. Gastroenterology 99:956-963.
Modigliani R., Mary J.Y., Simon J.F. (1990) Clinical biological and endoscopic picture of attacks of Crohn's disease; evolution on prednisolone. Gastroenterology 98:811-818.
Cellier C., Sahmoud T., Froguel E. (1994) Correlations between clinical activity, endoscopic severity, and biological parameters in colonic or ileocolonic Crohn's disease. A prospective multicentre study of 121 cases. Gut 35:231-235.
Sahmoud T., Modigliani R., Gendre J.P., Mary J.Y. (1994) Predicting relapse in quiescent cronh's disease patients: index construction and cross-validation. Gastroenterology , abstract; 106:A1048.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.