Article (Scientific journals)
Investigation of the death of calves after epileptiform seizures associated with metabolic disorders
Chevalier, Marine; Lebreton, Pascal; Garnier, Catherine et al.
2014In Cattle Practice, 22 (1), p. 10-16
Peer reviewed
 

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Keywords :
Hypomagnesaemia; hyperparathyroidism; hypovitaminosis; death; seizures; calves
Abstract :
[en] Death of calves after epileptiform seizures can be caused by metabolic disorders including hypomagnesaemia, although a range of other conditions may also be implicated and therefore also warrant investigation. Hypomagnesaemia is primarily observed in herds where calves are fed exclusively with either milk or milk substitute products. Hyperparathyroidism is associated with congestion and hypertrophy of the parathyroid gland and causes both hypercalcaemia and hypophosphataemia. However, its exact aetiology currently remains unclear. The purpose of this study was to explain epileptiform seizures in calves from a cattle herd presenting both deaths and decreased average daily gain (ADG). A Montbeliard herd with calves presenting epileptiform seizures from the age of five weeks was studied. The herd consisted of 39 cows and 46 calves. Tachycardia, nervousness and trampling, violent seizures of tetany lasting approximately 15 minutes were all observed, while opisthotonos was observed in 5 calves. Three of the latter calves died. The remaining calves presented a decreased ADG. Blood and urine biochemical assays were performed on 8 sick calves to determine the aetiology of the clinical signs. The assays revealed normo/hyper-calcaemia, hypophosphataemia and hypomagnesaemia, as well as hypocalciuria, hyperphosphaturia and hypomagnesuria. Deficiencies in iodine, iron and vitamins A, D3 and E were also reported in the herd. These calves could potentially be suffering from hyperparathyroidism. Hyperparathyroidism results in hypomagnesaemia, hypovitaminosis-A and, on occassion, hypercalcaemia and hypophosphataemia. This condition can lead to seizures, muscular problems, heart attacks and anorexia. The simultaneous occurrence of hypomagnesaemia, hyperparathyroidism and hypovitaminosis-A has been never described in related research literature. This is, therefore, in all likelihood a new metabolic disorder facing young cattle. Blood and urine biochemical assays are important tools for the detection of this pathological entity in calves. A dosage of parathyroid hormone (PTH) by the enzyme-linked immunosorbent assay (EIA) method using a kit suitable for cattle can be used to detect hyperparathyroidism.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Chevalier, Marine
Lebreton, Pascal
Garnier, Catherine
Rollin, Frédéric ;  Université de Liège - ULiège > Département clinique des animaux de production (DCP) > Médecine interne des équidés, des ruminants et des porcs
Guyot, Hugues  ;  Université de Liège - ULiège > Département clinique des animaux de production (DCP) > Gestion de la santé des ruminants
Language :
English
Title :
Investigation of the death of calves after epileptiform seizures associated with metabolic disorders
Alternative titles :
[fr] Etude de mortalité de veaux après épisodes de crises épileptiformes associés à des troubles métaboliques
Publication date :
April 2014
Journal title :
Cattle Practice
ISSN :
0969-1251
Publisher :
British Cattle Veterinary Association, Fretherne, United Kingdom
Volume :
22
Issue :
1
Pages :
10-16
Peer reviewed :
Peer reviewed
Available on ORBi :
since 07 April 2014

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