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Patent (Patents)
Double-muscling in mammals" Gene réf. Myostatin (MSTN).
Grobet, Luc; Georges, Michel
2000
 

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Abstract :
[en] A gene (cDNA) encoding a bovine myostatin protein. The nucleic acid coding sequence is identified as SEQ ID NO:1 and the protein sequence is identified as SEQ ID NO:2. A mutant gene (SEQ ID NO:3) in which the coding sequence lacks an 11-base pair consecutive sequence (SEQ ID NO:11) of the sequence encoding bovine protein having myostatin activity has been sequenced. It has been shown that cattle of the Belgian Blue breed homozygous for the mutant gene lacking myostatin activity are double-muscled. A method for determining the presence of muscular hyperplasia in a mammal is described. The method includes obtaining a sample of material containing DNA from the mammal and ascertaining whether a sequence of the DNA encoding (a) a protein having biological activity of myostatin, is present, and whether a sequence of the DNA encoding (b) an allelic protein lacking the activity of (a), is present. The absence of (a) and the presence of (b) indicates the presence of muscular hyperplasia in the mammal.
Disciplines :
Genetics & genetic processes
Inventor :
Grobet, Luc ;  Université de Liège - ULiège > Département de morphologie et pathologie > Embryologie
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Language :
English
Title (54) :
Double-muscling in mammals" Gene réf. Myostatin (MSTN).
Publication date (43-45) :
15 August 2000
Filing date (22) :
14 July 1997
Patent/publication number (10-11) :
6,103,466
Patent status (13) :
B
Priority number (30) :
non com
International classification (IPC) (51) :
C07K 14/435 (20060101); C07K 14/495 (20060101); C12Q 1/68 (20060101); C12N 15/85 (20060101); A61K 48/00 (20060101); C12Q 001/68 (); C12P 019/34 (); C07H 021/02 ()
European classification (ECLA) (52) :
NON COM
Applicant (71) :
ULg - Université de Liège
Publication organism (19) :
United Sates Patent
Available on ORBi :
since 11 March 2014

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