Reference : Changes in testosterone metabolism by the brain and cloacal gland during sexual matur...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Life sciences : Zoology
Changes in testosterone metabolism by the brain and cloacal gland during sexual maturation in the Japanese quail (Coturnix coturnix japonica).
Balthazart, Jacques mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
Schumacher, M. [> > > >]
Journal of Endocrinology
Yes (verified by ORBi)
[en] 17-Hydroxysteroid Dehydrogenases/metabolism ; Androstane-3,17-diol/metabolism ; Androstenedione/metabolism ; Animals ; Brain/metabolism ; Cloaca/metabolism ; Coturnix/metabolism ; Dihydrotestosterone/metabolism ; Female ; Hypothalamus/metabolism ; Luteinizing Hormone/blood ; Male ; Oxidoreductases/metabolism ; Pituitary Gland, Anterior/metabolism ; Preoptic Area/metabolism ; Quail/metabolism ; Sexual Maturation ; Testosterone/metabolism
[en] Testosterone metabolism in the brain and pituitary and cloacal glands of male and female Japanese quail was studied in vitro during sexual maturation (from 1 day to 5 weeks after hatching). The production of 5 alpha-dihydrotestosterone in the hyperstriatum and cloacal gland and that of androstenedione in the cloacal gland of males was highest at 1 day after hatching, which could be related to the peak of plasma androgens previously demonstrated in neonatal quail. 5 beta-Reductase activity was very high in the brain, but not the pituitary or cloacal glands of young chicks and decreased markedly, especially in the hypothalamus, during sexual maturation. As 5 beta-reduced metabolites of testosterone are inactive androgens, it is suggested that the decrease of 5 beta-reductase activity with age corresponds to a potentiation of the effects of testosterone at the level of the brain.

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