Frontal hypometabolism does not explain inhibitory dysfunction in Alzheimer disease

[en] A series of tasks assessing inhibitory processes was administered to patients with Alzheimer disease and control subjects. Two groups of patients with Alzheimer disease were examined: patients with hypometabolism restricted to the posterior (temporal and parietal) cerebral areas and patients with hypometabolism in both posterior and anterior (frontal) cerebral areas. The performances of the patients with Alzheimer disease were inferior to those of control subjects on all inhibitory tasks, but the two groups of patients obtained similar scores. These data indicate that frontal lobe hypometabolism is not necessary to produce inhibitory impairment in Alzheimer disease. Consequently, inhibitory dysfunction could be the consequence of a (partial) disconnection process between posterior and anterior cerebral areas.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurosciences & behavior
Neurology

Author, co-author :

Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie

Van der Linden, Martial ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive

Delrue, Gaël ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman

Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Language :

English

Title :

Frontal hypometabolism does not explain inhibitory dysfunction in Alzheimer disease

Publication date :

2002

Journal title :

Alzheimer Disease and Associated Disorders

ISSN :

0893-0341

eISSN :

1546-4156

Publisher :

Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania

Volume :

Issue :

4, Oct-Dec

Pages :

228-238

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.lww.com/resources/permissions/index.html

Available on ORBi :

since 07 July 2009

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