[en] A series of tasks assessing inhibitory processes was administered to patients with Alzheimer disease and control subjects. Two groups of patients with Alzheimer disease were examined: patients with hypometabolism restricted to the posterior (temporal and parietal) cerebral areas and patients with hypometabolism in both posterior and anterior (frontal) cerebral areas. The performances of the patients with Alzheimer disease were inferior to those of control subjects on all inhibitory tasks, but the two groups of patients obtained similar scores. These data indicate that frontal lobe hypometabolism is not necessary to produce inhibitory impairment in Alzheimer disease. Consequently, inhibitory dysfunction could be the consequence of a (partial) disconnection process between posterior and anterior cerebral areas.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurosciences & behavior Neurology
Author, co-author :
Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Van der Linden, Martial ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Delrue, Gaël ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
Frontal hypometabolism does not explain inhibitory dysfunction in Alzheimer disease
Publication date :
2002
Journal title :
Alzheimer Disease and Associated Disorders
ISSN :
0893-0341
eISSN :
1546-4156
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
Amieva H, Lafont S, Auriacombe S, et al. Inhibitory breakdown and dementia of the Alzheimer type: A general phenomenon? J Clin Exp Neuropsychol 2002;24:503-16.
Azari NP, Rapoport SI, Grady CL, et al. Patterns of interregional correlations of cerebral glucose metabolism rates in patients with dementia of the Alzheimer type. Neurodegeneration 1992;1:101-11.
Bachy-Langedock, N. Approche Cognitive des Troubles en Dénomination de L'Aphasie Adulte: Création et Étalonnage de Deux Batteries D'Analyse [Unpublished thesis dissertation]. Louvain, France: Université Catholique de Louvain, 1987.
Baddeley AD. Human Memory: Theory and Practice. Hove, United Kingdom: Erlbaum, 1990.
Baddeley AD, Logie R, Bressi S, et al. Dementia and working memory. Q J Exp Psychol 1986;38:603-18.
Baddeley AD, Bressi S, Della Sala S, et al. The decline of working memory in Alzheimer's disease: A longitudinal study. Brain 1991;114:2521-42.
Baddeley AD, Baddeley HA, Bucks RS, et al. Attentional control in Alzheimer's disease. Brain 2001;124:1492-508.
Bhutani GE, Montaldi D, Brooks DN, et al. A neuropsychologic investigation into frontal lobe involvement in dementia of the Alzheimer type. Neuropsychology 1992;6:211-24.
Brickenkamp R. Le Test D2 D'Attention Concentrée. Paris: Editest, 1966.
Brugger P, Monsch AU, Salmon DP, et al. Random number generation in dementia of the Alzheimer type: A test of frontal executive functions. Neuropsychologia 1996;34:97-103.
Burgess PW, Shallice T. Response suppression, initiation and strategy use following frontal lobe lesions. Neuropsychologia 1996;34:263-73.
Cabeza R, Nyberg L. Imaging cognition: II. An empirical review of 275 PET and fMRI studies. J Cognitive Neurosci 2000;12:1-47.
Collette F, Van der Linden M, Salmon E. Executive dysfunction in Alzheimer's disease. Cortex 1999;35:57-72.
Collette F, Van der Linden M, Salmon E. Relationships between cognitive performance and cerebral metabolism in Alzheimer's disease. Curr Psychol Lett 2000;1:55-69.
Collette F, Van der Linden M. Brain imaging of the central executive component of working memory. Neurosci Biobehav Rev 2002a;26:105-25.
Collette F, Van der Linden M. Attention disorders in degenerative syndromes. In: Leclercq M, Zimmerman P, eds. Applied Neuropsychology of Attention: Theoretical, Diagnosis and Rehabilitation Aspect. London: Psychology Press, 2002b:305-38.
Collette F, Van der Linden M, Juillerat A-C, et al. A cognitive neuropsychologic approach to Alzheimer's disease. In: Mulligan R, Van der Linden M, Juillerat AC, eds. Clinical Management of Early Alzheimer's Disease. Mahwah: Erlbaum, 2002c: In press.
Danckert J, Maruff P, Crowe S, et al. Inhibitory processes in covert orienting in patients with Alzheimer's disease. Neuropsychology 1998;12:225-41.
Faust ME, Balota DA. Inhibition of return and visuospatial attention in healthy older adults and individuals with dementia of the Alzheimer type. Neuropsychology 1997;11:13-29.
Frackowiak R, Friston K, Frith C, et al. Human Brain Function. London: Academic Press, 1997.
Friston KJ, Frith CD, Liddle PF, et al. The relationship between global and local changes in PET scans. J Cereb Blood Flow Metab 1990;10:458-66.
Friston KJ, Frith CD, Liddle PF, et al. Comparing functional (PET) images: The assessment of significant changes. J Cereb Blood Flow Metab 1991;11:690-9.
Fuster JM. Frontal lobes [Review]. Curr Opin Neurobiol 1993;3:160-5.
Grady CL, Furey ML, Pietrini P, et al. Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease. Brain 2001;124:739-56.
Hasher L, Zacks RT, May CP. Inhibitory control, circardian arousal, and age. In: Gopher D, Koriat A, eds. Attention and Performance: XVII. Cognitive Regulation of Performance: Interaction of Theory and Application. Cambridge, MA: MIT Press, 1999;653-75.
Horwitz B, McIntosh AR, Haxby JV, et al. Network analysis of PET-mapped visual pathways in Alzheimer type dementia. Neuroreport 1995;6:2287-92.
Johnson JK, Head E, Kim R, et al. Clinical and pathologic evidence for a frontal variant of Alzheimer disease. Arch Neurol 1999;56:1233-9.
Kanne SM, Balota DA, Storandt M, et al. Relating anatomy to function in Alzheimer's disease: Neuropsychologic profiles predict regional neuropathology 5 years later. Neurology 1998;50:979-85.
Kessler J, Mielke R, Grond M, et al. Frontal lobe tasks do not reflect frontal lobe functioning in patients with probable Alzheimer's disease. Int J Neurosci 2000;104:1-15.
Lafleche G, Albert MS. Executive function deficits in mild Alzheimer's disease. Neuropsychology 1995;9:313-20.
Langley LK, Overmier JB, Knopman DS, et al. Inhibition and habituation: Preserved mechanisms of attentional selection in aging and Alzheimer's disease. Neuropsychology 1998;12:353-66.
Leuchter AF, Newton TF, Cook IA, et al. Changes in brain functional connectivity in Alzheimer-type dementia and multi-infarct dementia. Brain 1992;115:1543-61.
Mann UM, Mohr E, Gearing M, et al. Heterogeneity in Alzheimer's disease: Progression rate segregated by distinct neuropsychologic and cerebral metabolic profiles. J Neurol Neurosurg Psychiatry 1992;55:956-9.
Mattis S. Dementia Rating Scale. Windsor, NFER-Nelson, 1973.
McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology 1984;34:939-44.
Mega MS, Chen SS, Thompson PM, et al. Mapping histology to metabolism: Coregistration of stained whole-brain sections to premortem PET in Alzheimer's disease. Neuroimage 1997;5:147-53.
Monsch AU, Bondi MW, Salmon DP, et al. Clinical validity of the Mattis dementia rating scale in detecting dementia of the Alzheimer type. Arch Neurol 1995;52:899-904.
Morris RG. Neurobiologic correlates of cognitive dysfunction. In: Morris RG, ed. The Cognitive Neuropsychology of Alzheimer-Type Dementia. Oxford: Oxford University Press, 1996:223-54.
Neill WT. Inhibition and facilitation processes in selective attention. J Exp Psychol 1977;3:444-50.
Pasquier F, Lebert F, Grymonprez L, et al. Verbal fluency in dementia of frontal lobe type and dementia of Alzheimer type. J Neurol Neurosurg Psychiatry 1995;58:81-4.
Perret E. The left frontal lobe of man and the suppression of habitual responses in verbal categorical behavior. Neuropsychologia 1974;12:323-30.
Phelps ME, Huang SE, Hoffman EJ, et al. Tomographic measurement of local cerebral metabolic rate in humans with (F-18) 2-fluoro-2-deoxyglucose: Validation of method. Ann Neurol 1979;6:371-88.
Salmon E, Sadzot B, Maquet P, et al. Differential diagnosis of Alzheimer's disease with PET. J Nucl Med 1994;35:391-8.
Simone PM, Baylis GC. The role of attention in a spatial memory task in Alzheimer disease patients. Alzheimer Dis Assoc Disord 1997;11:140-52.
Spieler DH, Balota DA, Faust ME. Stroop performance in healthy younger and older adults and in individuals with dementia of the Alzheimer's type. J Exp Psychol 1996;22:461-79.
Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol 1935;6:643-61.
Sullivan MP, Faust ME, Balota DA. Identity negative priming in older adults and individuals with dementia of the Alzheimer type. Neuropsychology 1995;9:537-55.
Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System. An Approach to Cerebral Imaging. Stuttgart, Germany: Thieme, 1988.
Tipper S. The negative priming effect: Inhibitory effects of ignored primes. Q J Exp Psychol 1985;37:571-90.
Troyer AK, Moscovitch M, Winocur G, et al. Clustering and switching on verbal fluency tests in Alzheimer's and Parkinson's disease. J Int Neuropsychol Soc 1998;4:137-43.
Waldemar G, Bruhn P, Kristensen M, et al. Heterogeneity of neocortical cerebral blood flow deficits in dementia of the Alzheimer type: A [99mTC]-D,L-HMPAO SPECT study. J Neurol Neurosurg Psychiatry 1994;57:285-95.
Weinberger DR. A connectionist approach to the prefrontal cortex. J Neuropsychiatry Clin Neurosci 1993;5:241-53.
Wilson JTL. Visual short term memory. In: Stachowiack FJ, ed. Development in the Assessment and Rehabiliation of Brain Damaged Patients. Tübingen, Germany: Gunter Narr Verlag, 1993:107-10.
Zimmermann P, Fimm B. Tests D'Evaluation de L'Attention (TEA). Würselen, Germany: Psytest, 1994.
