Reference : The Tax protein and the minichromosome maintenance protein complex MCM2-7 affect cell...
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/162316
The Tax protein and the minichromosome maintenance protein complex MCM2-7 affect cell replication and viral transcription
English
Barez, Pierre-Yves mailto [Université de Liège - ULiège > > > Doct. sc. agro. & ingé. biol.]
Carpentier, Alexandre mailto [Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc. >]
Boxus, Mathieu []
Willems, Luc mailto [Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc. >]
7-Jan-2014
Retrovirology
BioMed Central
11
S1
96
Yes (verified by ORBi)
International
1742-4690
London
United Kingdom
[en] HTLV-1 ; Tax ; MCM2-7 ; Replication Timing ; Viral Transcription
[en] The Tax oncoprotein plays a key role in the mechanisms of transformation, viral persistence and pathogenicity. Recently, we showed that Tax interacts with the minichromosome maintenance MCM2-7 helicase and binds to origins of DNA replication (Boxus et al, 2012 Blood 119:151). In fact, Tax modulates the spatiotemporal program of origin activation during the S phase of cell cycle. By this mechanism, Tax accelerates S phase progression through early firing of late replication origins. By interacting with the 5’ LTR, the MCM2-7 complex also modulates Tax transactivation. Together, our data thus demonstrates that interaction between Tax and MCM2-7 modulates reprogramming of replication origins as well as viral transcription.
Researchers ; Students
http://hdl.handle.net/2268/162316
10.1186/1742-4690-11-S1-P96
http://www.retrovirology.com/content/11/S1/P96

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