Multifactorial Relationship Between 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography Signaling and Biomechanical Properties in Unruptured Aortic Aneurysms

NCHIMI LONGANG, Alain; CHERAMY-BIEN, Jean-Paul; Gasser, Thomas Christian; NAMUR, Gauthier; Gomez, Pierre; SEIDEL, Laurence; Albert, Adelin; Defraigne, Jean-Olivier; Labropoulos, Nicos; Sakalihasan, Natzi

doi:10.1161/CIRCIMAGING.112.000415

Article (Scientific journals)

Multifactorial Relationship Between 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography Signaling and Biomechanical Properties in Unruptured Aortic Aneurysms

NCHIMI LONGANG, Alain; CHERAMY-BIEN, Jean-Paul; Gasser, Thomas Christian et al.

2014 • In Circulation: Cardiovascular Imaging, 7, p. 82-91

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/161909

DOI
10.1161/CIRCIMAGING.112.000415

PubMed
24190906

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Keywords :

Aneurysm; aorta; tomography

Abstract :

[en] BACKGROUND: -The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations (FES) and 18F-fluoro-deoxyglucose (18F-FDG) positron emission tomography (PET). METHODS AND RESULTS: -The study included 53 patients (45 males) with aortic aneurysms, 47 infrarenal (AAA) and 6 thoracic (TAA), who had at least one 18F-FDG PET/computed tomography. Over a 30-month period, more clinical events occurred in patients with increased 18F-FDG uptake on their last examination than in those without (5/18 (28%) vs. 2/35 (6%); P=0.03). Wall stress and stress/strength index computed by FES and 18F-FDG uptake were evaluating a total of 68 examinations. 25 (38%) examinations demonstrated at least one aneurysm wall area of increased 18F-FDG uptake. The mean number of these areas per examination was 1.6 (18/11) in TAAs vs. 0.25 (14/57) in AAAs, while the mean number of increased uptake areas co-localizing with highest wall stress and stress/strength index areas was 0.55 (6/11) and 0.02 (1/57), respectively. Quantitatively, 18F-FDG PET uptake correlated positively with both wall stress and stress/strength index (P<0.05). 18F-FDG uptake was particularly high in subjects with personal history of angina pectoris and familial aneurysm. CONCLUSIONS: -Increased 18F-FDG PET uptake in aortic aneurysms is strongly related to aneurysm location, wall stress as derived by FES and patient's risk factors such as acquired and inherited susceptibilities.

Disciplines :

Surgery
Radiology, nuclear medicine & imaging

Author, co-author :

NCHIMI LONGANG, Alain ; Centre Hospitalier Universitaire de Liège - CHU > Radiodiagnostic

CHERAMY-BIEN, Jean-Paul ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire

Gasser, Thomas Christian

NAMUR, Gauthier ; Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire et imagerie oncologique

Gomez, Pierre

SEIDEL, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > Service d'Informations médico économiques (SIME)

Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique

Defraigne, Jean-Olivier ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique

Labropoulos, Nicos

Sakalihasan, Natzi ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire

Language :

English

Title :

Multifactorial Relationship Between 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography Signaling and Biomechanical Properties in Unruptured Aortic Aneurysms

Publication date :

2014

Journal title :

Circulation: Cardiovascular Imaging

ISSN :

1941-9651

eISSN :

1942-0080

Publisher :

Lippincott Williams & Wilkins, United States

Volume :

Pages :

82-91

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 January 2014

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