Reference : Heat-triggered drug release systems based on mesoporous silica nanoparticles filled w...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/161758
Heat-triggered drug release systems based on mesoporous silica nanoparticles filled with a maghemite core and phase-change molecules as gatekeepers
English
Liu, Ji [Université de Liège - ULiège, University of Bordeaux, CNRS > Department of Chemistry (Liège), ICMCB (Bordeaux) > Center for Education and Research on Macromolecules (CERM, Liège) > >]
Detrembleur, Christophe mailto [Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
De Pauw-Gillet, Marie-Claire mailto [Université de Liège - ULiège > Laboratory of Mammalian Cell Culture (GIGA-R) > > >]
Mornet, Stéphane [University of Bordeaux, CNRS > ICMCB > > >]
Vander Elst, Luce [University of Mons-Hainaut (UMH) > Department of General, Organic & Biomedical Chemistry > NMR & Molecular Imaging > >]
Laurent, Sophie [University of Mons-Hainaut (UMH) > Department of General, Organic & Biomedical Chemistry > NMR & Molecular Imaging > >]
Jérôme, Christine mailto [Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Duguet, Etienne [University of Bordeaux, CNRS > ICMCB > > >]
7-Jan-2014
Journal of Materials Chemistry B
2
1
59-70
Yes
International
2050-750X
2050-7518
[en] biomaterial ; nanomedicine
[en] Core–shell nanoparticlesmade of a maghemite core and a mesoporous silica shell were developed as drug delivery systems (DDS). Doxorubicin® (DOX, DNA intercalating drug) was loaded within the mesoporous cavities, while phase-change molecules (PCMs), e.g. 1-tetradecanol (TD) with a melting temperature (Tm) of 39 °C, were introduced as gatekeepers to regulate the release behaviours. An overall loading amount of ca. 20 wt% (TD/DOX ca. 50/50 wt/wt) was confirmed. Heat-triggered release of DOX evidenced a “zero premature release” (<3% of the entire payload in 96 h release) under physiological conditions (37°C), and however, a sustainable release (ca. 40% of the entire payload in 96 h) above Tm of TD (40 °C). It also demonstrated the possibility to deliver drug payloads in small portions (pulsatile release mode) via multiple heating on/off cycles, due to the reversible phase change of the PCMs. In vitro heattriggered release of DOX within cell culture of the MEL-5 melanoma cell line was also tested. It was found that DOX molecules were trapped efficiently within the mesopores even after internalization within the cytoplasm of MEL-5 cells at 37 °C, with the potential toxicity of DOX strongly quenched (>95% viability after
72 h incubation). However, continuous cell apoptosis was detected at cell culture temperature above Tm of TD, due to the heat-triggered release of DOX (<50% viability after 72 h incubation at 40 °C). Moreover, due to the presence of a maghemite core within the DDS, T2-weighted magnetic resonance imaging performance was also confirmed. These as-designed core–shell nanoparticles are envisaged to become promising DDS for “on-demand” heat-triggered release.
Center for Education and Research on Macromolecules (CERM)
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The Erasmus Mundus international doctoral school IDS-FunMat
Researchers
http://hdl.handle.net/2268/161758
10.1039/c3tb21229g
http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/c3tb21229g#!divAbstract

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