[en] Core–shell nanoparticlesmade of a maghemite core and a mesoporous silica shell were developed as drug delivery systems (DDS). Doxorubicin® (DOX, DNA intercalating drug) was loaded within the mesoporous cavities, while phase-change molecules (PCMs), e.g. 1-tetradecanol (TD) with a melting temperature (Tm) of 39 °C, were introduced as gatekeepers to regulate the release behaviours. An overall loading amount of ca. 20 wt% (TD/DOX ca. 50/50 wt/wt) was confirmed. Heat-triggered release of DOX evidenced a “zero premature release” (<3% of the entire payload in 96 h release) under physiological conditions (37°C), and however, a sustainable release (ca. 40% of the entire payload in 96 h) above Tm of TD (40 °C). It also demonstrated the possibility to deliver drug payloads in small portions (pulsatile release mode) via multiple heating on/off cycles, due to the reversible phase change of the PCMs. In vitro heattriggered release of DOX within cell culture of the MEL-5 melanoma cell line was also tested. It was found that DOX molecules were trapped efficiently within the mesopores even after internalization within the cytoplasm of MEL-5 cells at 37 °C, with the potential toxicity of DOX strongly quenched (>95% viability after
72 h incubation). However, continuous cell apoptosis was detected at cell culture temperature above Tm of TD, due to the heat-triggered release of DOX (<50% viability after 72 h incubation at 40 °C). Moreover, due to the presence of a maghemite core within the DDS, T2-weighted magnetic resonance imaging performance was also confirmed. These as-designed core–shell nanoparticles are envisaged to become promising DDS for “on-demand” heat-triggered release.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering Chemistry
Author, co-author :
Liu, Ji ; Université de Liège - ULiège, University of Bordeaux, CNRS > Department of Chemistry (Liège), ICMCB (Bordeaux) > Center for Education and Research on Macromolecules (CERM, Liège)
Detrembleur, Christophe ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
I. I. Slowing J. L. Vivero-Escoto C. W. Wu V. S. Lin Adv. Drug Delivery Rev. 2008 60 1278 1288
J. M. Rosenholm C. Sahlgren M. Linden Nanoscale 2010 2 1870 1883
J. E. Lee N. Lee T. Kim J. Kim T. Hyeon Acc. Chem. Res. 2011 44 893 902
M. Manzano M. Colilla M. Vallet-Regi Expert Opin. Drug Delivery 2009 6 1383 1400
P. P. Yang Z. W. Quan Z. Y. Hou C. X. Li X. J. Kang Z. Y. Cheng J. Lin Biomaterials 2009 30 4786 4795
B. S. Chang X. Y. Sha J. Guo Y. F. Jiao C. C. Wang W. L. Yang J. Mater. Chem. 2011 21 9239 9247
L. Y. Xia M. Q. Zhang C. E. Yuan M. Z. Rong J. Mater. Chem. 2011 21 9020 9026
C. Tourne-Peteilh D. A. Lerner C. Charnay L. Nicole S. Begu J. M. Devoisselle ChemPhysChem 2003 4 281 286
D. Tarn C. E. Ashley M. Xue E. C. Carnes J. I. Zink C. J. Brinker Acc. Chem. Res. 2013 46 792 801
C. Coll A. Bernardos R. Martinez-Manez F. Sancenon Acc. Chem. Res. 2013 46 339 349
P. Yang S. Gai J. Lin Chem. Soc. Rev. 2012 41 3679 3698
M. W. Ambrogio C. R. Thomas Y. L. Zhao J. I. Zink J. F. Stoddart Acc. Chem. Res. 2011 44 903 913
I. I. Slowing B. G. Trewyn S. Giri V. S. Y. Lin Adv. Funct. Mater. 2007 17 1225 1236
E. Aznar M. D. Marcos R. Martinez-Manez F. Sancenon J. Soto P. Amoros C. Guillem J. Am. Chem. Soc. 2009 131 6833 6843
R. Liu Y. Zhang X. Zhao A. Agarwal L. J. Mueller P. Y. Feng J. Am. Chem. Soc. 2010 132 1500 1501
J. L. Vivero-Escoto I. I. Slowing C. W. Wu V. S. Y. Lin J. Am. Chem. Soc. 2009 131 3462 3463
T. D. Nguyen Y. Liu S. Saha K. C. F. Leung J. F. Stoddart J. I. Zink J. Am. Chem. Soc. 2007 129 626 634
C. L. Zhu C. H. Lu X. Y. Song H. H. Yang X. R. Wang J. Am. Chem. Soc. 2011 133 1278 1281
S. W. Choi Y. Zhang Y. Xia Angew. Chem., Int. Ed. 2010 49 7904 7908
G. D. Moon S. W. Choi X. Cai W. Li E. C. Cho U. Jeong L. V. Wang Y. Xia J. Am. Chem. Soc. 2011 133 4762 4765
L. Tian N. Gandra S. Singamaneni ACS Nano 2013 7 4252 4260
N. Singh A. Karambelkar L. Gu K. Lin J. S. Miller C. S. Chen M. J. Sailor S. N. Bhatia J. Am. Chem. Soc. 2011 133 19582 19585
A. Bernardos E. Aznar C. Coll R. Martinez-Manez J. M. Barat M. D. Marcos F. Sancenon A. Benito J. Soto J. Controlled Release 2008 131 181 189
R. Liu X. Zhao T. Wu P. Y. Feng J. Am. Chem. Soc. 2008 130 14418 14419
R. Casasus M. D. Marcos R. Martinez-Manez J. V. Ros-Lis J. Soto L. A. Villaescusa P. Amoros D. Beltran C. Guillem J. Latorre J. Am. Chem. Soc. 2004 126 8612 8613
E. Ruiz-Hernandez A. Baeza M. Vallet-Regi ACS Nano 2011 5 1259 1266
R. Massart IEEE Trans. Magn. 1981 17 1247 1248
J. Kim H. S. Kim N. Lee T. Kim H. Kim T. Yu I. C. Song W. K. Moon T. Hyeon Angew. Chem., Int. Ed. 2008 47 8438 8441
Q. Cai Z. S. Luo W. Q. Pan Y. W. Fan X. H. Chen F. Z. Cui Chem. Mater. 2001 13 258 263
V. I. Shubayev T. R. Pisanic S. Jin Adv. Drug Delivery Rev. 2009 61 467 477
H. S. Choi W. Liu P. Misra E. Tanaka J. P. Zimmer B. Itty Ipe M. G. Bawendi J. V. Frangioni Nat. Biotechnol. 2007 25 1165 1170
Q. He Z. Zhang F. Gao Y. Li J. Shi Small 2011 7 271 280
J. Panyam V. Labhasetwar Adv. Drug Delivery Rev. 2003 55 329 347
A. S. Karakoti S. Das S. Thevuthasan S. Seal Angew. Chem., Int. Ed. 2011 50 1980 1994
P. Nativo I. A. Prior M. Brust ACS Nano 2008 2 1639 1644
M. J. Roberts M. D. Bentley J. M. Harris Adv. Drug Delivery Rev. 2002 54 459 476
J. Xie C. Xu N. Kohler Y. Hou S. Sun Adv. Mater. 2007 19 3163 3166
Y. Deng D. Qi C. Deng X. Zhang D. Zhao J. Am. Chem. Soc. 2008 130 28 29
A. P. Leonov J. Zheng J. D. Clogston S. T. Stern A. K. Patri A. Wei ACS Nano 2008 2 2481 2488
I. Gorelikov N. Matsuura Nano Lett. 2008 8 369 373
J. Kim J. E. Lee J. Lee J. H. Yu B. C. Kim K. An Y. Hwang C. H. Shin J. G. Park J. Kim T. Hyeon J. Am. Chem. Soc. 2006 128 688 689
F. Muhammad M. Guo W. Qi F. Sun A. Wang Y. Guo G. Zhu J. Am. Chem. Soc. 2011 133 8778 8781
Y. Zhao L. N. Lin Y. Lu S. F. Chen L. Dong S. H. Yu Adv. Mater. 2010 22 5255 5259
Y. J. Yang X. Tao Q. Hou Y. Ma X. L. Chen J. F. Chen Acta Biomater. 2010 6 3092 3100
M. T. Zhu B. Wang Y. Wang L. Yuan H. J. Wang M. Wang H. Ouyang Z. F. Chai W. Y. Feng Y. L. Zhao Toxicol. Lett. 2011 203 162 171
C. Zhang B. Wangler B. Morgenstern H. Zentgraf M. Eisenhut H. Untenecker R. Kruger R. Huss C. Seliger W. Semmler F. Kiessling Langmuir 2007 23 1427 1434
J. M. Rosenholm A. Meinander E. Peuhu R. Niemi J. E. Eriksson C. Sahlgren M. Linden ACS Nano 2009 3 197 206
P. Vader L. J. van der Aa J. F. Engbersen G. Storm R. M. Schiffelers J. Controlled Release 2010 148 106 109
Y. Zhu Y. Fang S. Kaskel J. Phys. Chem. C 2010 114 16382 16388
A. Bhirde J. Xie M. Swierczewska X. Chen Nanoscale 2011 3 142 153
E. Duguet S. Vasseur S. Mornet J. M. Devoisselle Nanomedicine 2006 1 157 168
S. Laurent D. Forge M. Port A. Roch C. Robic L. Vander Elst R. N. Muller Chem. Rev. 2008 108 2064 2110
F. Liu S. Laurent H. Fattahi L. Vander Elst R. N. Muller Nanomedicine 2011 6 519 528
A. Roch R. Muller P. Gillis J. Phys. Chem. C 1999 110 5403 5411
F. Ye S. Laurent A. Fornara L. Astolfi J. Qin A. Roch A. Martini M. S. Toprak R. N. Muller M. Muhammed Contrast Media Mol. Imaging 2012 7 460 468