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Poster (Scientific congresses and symposiums)
Tilted peptides in amyloidogenic proteins
Crowet, Jean-Marc; Brasseur, Robert; Lins, Laurence
2004Peptide Membrane Interaction
 

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Abstract :
[en] Amyloidogenic proteins are of interest in the study of transconformational processes because they undergo a major conformational change leading to amyloid fibrils formation by a self-assembly of their misfolded form.   Amyloid fibrils are implicated in several diseases such as Alzheimer, Parkinson or Creutzfeldt-Jakob diseases. Fibrils have varying lengths up to few micrometers, they are unbranched and the individual β strands are oriented perpendicular to the long axis of the fibril. Moreover, the conformational changes induce an increase in the β content. However little is known about the mechanisms of transconformation, the subsequent aggregation and the mechanism toxicity of these proteins. Study of these misfolded proteins, and particularly study of their conformation, is difficult due to their high tendency to aggregate in solution.   Regarding the transconformational mechanisms, it’s interesting to study the potential role of tilted peptides because they possess several properties which could be involved in this process. They can adopt  or β conformation depending on the environment. When helical, they can destabilize the hydrophilic/hydrophobic interface of an organised system. They were notably found in the domain undergoing transconformation in the Aβ protein (Alzheimer’s disease) and in PrP (prion diseases). They could have an important role in the first step of the transconformational process ; their destabilizing properties could also be implicated in the toxicity of these proteins.
Research center :
Centre de Biophysique Moléculaire Numérique
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Crowet, Jean-Marc ;  Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Brasseur, Robert ;  Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Lins, Laurence  ;  Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Language :
English
Title :
Tilted peptides in amyloidogenic proteins
Publication date :
October 2004
Number of pages :
A0
Event name :
Peptide Membrane Interaction
Event organizer :
Professeur Robert Brasseur
Event place :
Namur, Belgium
Event date :
du 9 au 12 octobre 2004
Audience :
International
Name of the research project :
Etude de l’implication des peptides obliques dans les phénomènes de transconformation
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
Available on ORBi :
since 10 December 2013

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