Dynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus: differences in PCB profile between compartments of transfer and changes during the lactation period
[en] The composition of the PCB mixture which is transferred from mother to pup in grey seals Halichoerus grypus throughout lactation was measured in the successive compartments of transfer: maternal blubber, maternal serum, milk and pup serum. Mother-pup pairs were captured regularly between birth and weaning on the Isle of May, Scotland. The PCB profiles of the different compartments of transfer consisted mainly of congeners 153, 138, 180, 187, 170 and 101, which made up 85% of the total PCB burden. Outer blubber contained higher relative concentrations (R-153) Of hepta-, octa-, and nona-chlorinated congeners (higher chlorinated congeners) than inner blubber, at both early (less than or equal to 5 d) and late (greater than or equal to 11 d) lactation. There was no change in the composition of the outer blubber layer between early and late lactation, while in the inner blubber, there was a slight increase in the R153 of higher chlorinated congeners at late lactation. In maternal serum, profiles changed towards having a higher proportion of higher chlorinated congeners as lactation progressed, but in milk, the PCB pattern stayed constant throughout lactation. Surprisingly, in pup serum profiles also changed towards higher R153 of higher chlorinated congeners at late lactation compared to early lactation, which was different to the pattern observed in milk. In all body compartments, higher proportions of higher chlorinated congeners were associated with higher concentrations of total PCBs. Maternal blubber and pup serum contained a higher R153 of higher chlorinated congeners than milk and, to a lesser extent, maternal serum. Thus biomagnification of the higher chlorinated congeners was recorded in pup serum.
Debier, Cathy; Université Catholique de Louvain - UCL > Unité de Biochimie de la Nutrition (BNUT)
Pomeroy, Paddy P.; University of St Andrews (Scotland) > NERC Sea Mammal Research Unit > Gatty Marine Laboratory
Dupont, Cédric; Université de Liège - ULiège > Institut de Zoologie > Laboratoire d'Ecologie animale et d'Ecotoxicologie
Joiris, Claude; Free University of Brussels > Laboratory for Ecotoxicology and Polar Biology
Comblin, Vinciane; Université de Liège - ULiège > Institut de Zoologie > Laboratoire d'Ecologie animale et d'Ecotoxicologie
Le Boulenge, Eric; Université Catholique de Louvain - UCL > Unité de Biométrie et analyse des données (BIOM)
Larondelle, Yvan; Université Catholique de Louvain - UCL > Unité de Biochimie de la Nutrition (BNUT)
Thomé, Jean-Pierre ; Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Ecologie animale et écotoxicologie
Language :
English
Title :
Dynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus: differences in PCB profile between compartments of transfer and changes during the lactation period
Addison RF, Brodie PF (1987) Transfer of organochlorine residues from blubber through the circulatory system to milk in the lactating grey seal Halichoerus grypus. Can J Fish Aquat Sci 44:782-786
Andersen G, Kovacs KM, Lydersen C, Skaare JU, Gjertz I, Jenssen BM (2001) Concentrations and patterns of organochlorine contaminants in white whales (Delphinapterus leucas) from Svalbard, Norway. Sci Total Environ 264:267-281
Bacon CE, Jarman WM, Costa DP (1992) Organochlorine and polychlorinated biphenyl levels in pinniped milk from the Arctic, the Antarctic, California and Australia. Chemosphere 24:779-791
Bard SM (1999) Global transport of anthropogenic contaminants and the consequences for the Artic marine ecosystem. Mar Pollut Bull 38:356-379
Beckmen KB, Ylitalo GM, Towell RG, Krahn MM, O'Hara TM, Blake JE (1999) Factors affecting organochlorine contaminant concentrations in milk and blood of northern fur seal (Callorhinus ursinus) dams and pups from St George Island, Alaska. Sci Total Environ 231:183-200
Bernhoft A, Wiig Ø, Skaare JU (1997) Organachlorines in polar bears (Ursus rnaritimus) at Svalbard. Environ Pollut 95:159-175
Bernt KE, Hammill MO, Lebeuf M, Kovacs KM (1999) Levels and patterns of PCBs and OC pesticides in harbour and grey seals from the St Lawrence Estuary, Canada. Sci Total Environ 243/244:243-262
Boon JP, Oostingh I, van der Meet J, Hillebrand MT (1994) A model for the bioaccumulation of chlorobiphenyl congeners in marine mammals. Environ Toxicol Pharmacol 270:237-251
Cleemann M, Riget F, Paulsen GB, de Boer J, Dietz R (2000) Organochlorines in Greenland ringed seals (Phoca hispida). Sci Total Environ 245:103-116
Debier C, Pomeroy PP, Mignolet E, Baret PV, Larondelle Y (2002) Vitamin E status and the dynamics of its transfer between mother and pup during lactation in grey seals (Halichoerus grypus) during lactation. Can J Zool 80:1-11
Debier C, Pomeroy PP, Dupont C, Joiris C, Comblin V, Le Boulengé E, Larondelle Y, Thomé JP (2003) Quantitative dynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus. Mar Ecol Prog Ser 247:237-248
Espeland O, Kleivane L, Haugen S, Skaare JU (1997) Organochlorines in mother and pup pairs in two Arctic seal species: harp seal (Phoca groenlandica) and hooded seal (Cystophora cristata). Mar Environ Res 44:315-330
Grahl-Nielsen O, Hammill MO, Lydersen C, Wahlstrom S (2000) Transfer of fatty acids from female seal blubber via milk to pup blubber. J Comp Physiol B 170:277-283
Heidmann WA, Staats de Yanks G, Büthe A, Rüssel-Sinn H (1992) Correlation between concentration and composition of PCB mixtures in seals (Phoca vitulina). Chemosphere 24:1111-1117
Henderson RJ, Kalogeropoulos N, Alexis MN (1994) The lipid composition of selected tissues from a Mediterranean monk seal, Monachus rnonachus. Lipids 29:577-582
Hong CS, Calambokidis J, Bush B, Steiger GH, Shaw S (1996) Polychlorinated biphenyls and organochlorine pesticide in harbour seal pups from the inland waters of Washington State. Environ Sci Technol 30:837-844
Hugla JL, Philippart JC, Kremers P, Goffinet G, Thomé JP (1995) PCB contamination of the common barbel, Barbus barbus (pisces, cyprinidae), in the river Meuse in relation to hepatic monooxygenase activity and ultrastructural liver change. Neth J Aquat Ecol 29:135-145
Jenssen BM, Skaare JU, Ekker M, Vongraven D, Lorentsen SH (1996) Organochlorine compounds in blubber, hver and brain in neonatal grey seal pups. Chemosphere 32:2115-2125
Juchau MR (1983) Disposition of chemical contaminants in maternal-embryonic/fetal systems. In: Saxena J (ed) Hazard assessment of chemicals: Current developments, Vol 2. Academic Press, New York, p 95-132
Kleivane L, Espeland O, Fagerheim KA, Hylland K, Polder A, Skaare JU (1997) Organochlorine pesticides and PCBs in the east ice harp seal (Phoca groenlandica) population. Mar Environ Res 43:117-130
Law RJ, Allchin CR, Harwood J (1989) Concentration of organochlonne compounds in the blubber of seals from eastern and north-eastern England, 1988. Mar Pollut Bull 20:110-115
Mössner S, Ballschmiter K (1997) Marine mammals as global pollution indicators for organochlorines. Chemosphere 34:1285-1296
Muir DCG, Norstrom RI, Simon M (1988) Organochlorine contaminants in Arctic marine food chains: accumulation of specific polychlormated biphenyls and chlordane-related compounds. Environ Sci Technol 22:1071-1079
Pomeroy PP, Green N, Hall A J, Walton M, Jones K, Harwood J (1996) Congener-specific exposure of grey seal (Halichoerus grypus) pups to chlorinated biphenyls during lactation. Can J Fish Aquat Sci 53:1526-1534
Ross PS (2000) Marine mammals as sentinels in ecological risk assessments. Human Ecol Risk Assess 6:29-46
Ross PS, De Swart RL, Addison R, Van Loveren H, Vos J, Osterhaus A (1996) Contaminant-induced immunotoxicity in harbour seals: wildlife at risk? Toxicology 112:157-169
Safe SH (1994) Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 24:87-149
SAS/STAT (1990) User's guide, Vol 2 GLM-VARCOMP Version 6, 4th edn. SAS Institute, Cary, NC
Tanabe S, Tatsukawa R, Maruyama K, Miyazaki N (1982) Transplacental transfer of PCBs and chlorinated hydrocarbon pesticides from the pregnant striped dolphin (Stenella coeruleoalba) to her fetus. Agric Biol Chem 46(5):1249-1254
Tanabe S, Sung JK, Choi DY, Baba N, Kiyota M, Yoshida K, Tatsukawa R (1994) Persistent organochlorine residues in northern fur seal from the Pacific coast of Japan since 1971. Environ Pollut 85:305-314
Wolkers J, Burkow IC, Lydersen C, Dahle S, Monshouwer M, Witkamp RF (1998) Congener specific PCB and polychlorinated camphene (toxaphene) levels in Svalbard ringed seals (Phoca hispida) in relation to sex, age, condition and cytochrome P450 enzyme activity. Sci Total Environ 216:1-11
