Article (Scientific journals)
BLOOD GROUPS, HEMOGLOBIN PHENOTYPES AND CLINICAL DISORDERS OF CONSANGUINEOUS YANSI POPULATION
Munlemvo Mavanga, Nana; BOEMER, François; SEIDEL, Laurence et al.
2013In World Journal of Hematology, 2 (4), p. 109-114
Peer reviewed
 

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Keywords :
Blood group antigens; blood group phenotype; G6PD deficiency; sickle-cell anemia; hemoglobin electrophoresis; clinical disorders; consanguinity; Yansi
Abstract :
[en] AIM To study frequency of blood groups, prevalence of sickle-cell anemia trait and glucose-6-phosphate dehydrogenase deficiency, among consanguineous Yansi tribe. METHODS A total of 525 blood samples were collected, of which 256 among the Yansi population, and 269 for the unrelated control group in the Bandundu province of Democratic Republic of Congo. Blood group antigens were determined in the following systems: ABO, Rh, Kell, Duffy, Kidd and MNS. Blood grouping and extended phenotype tests were performed according to standard immunohematological procedures. Spot tests and tandem mass spectrometry were used respectively for the assessment of glucose-6-phosphate dehydrogenase deficiency and sickle-cell anemia trait. RESULTS The frequency of ABO phenotypes conformed to the following order O>A>B>AB with notably 62.5, 23.8, 12.1 and 1.6% for the Yansi, and 54.6, 27.5, 14.1 and 3.7% for the unrelated control group, respectively (P=0.19). As for the Rh phenotypes, the most frequent were ccD.ee, ccD.Ee, CcD.ee, corresponding to 71.5, 12.1 and 12.1% for the Yansi, and 70.6, 15.6 and 8.2%, for the unrelated control group (P=0.27). The frequency of MN and Ss phenotypes were statistically different between groups (P=0.0021 and P=0.0006). G6PD deficiency was observed in 11.3% of subjects in the Yansi group, and in 12.4% of controls (P = 0.74). The sickle-cell anemia trait was present in 22.4% of Yansi subjects and 17.8% in the control group (P=0.24). Miscarriages and deaths in young age were more common among Yansi people. CONCLUSION This study shows a significant difference in MNS blood group distribution between the Yansi tribe and a control population. The distribution of other blood groups and the prevalence of hemoglobinopathies did not differ in the Yansi tribe.
Disciplines :
Hematology
Author, co-author :
Munlemvo Mavanga, Nana ;  Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.
BOEMER, François  ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
SEIDEL, Laurence  ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'Informations médico économiques (SIME)
Nkebolo Malafu, André;  Institut Supérieur des Techniques Médicales (ISTM/Kinshasa) > Biologie
GOTHOT, André ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
GERARD, Christiane ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Language :
English
Title :
BLOOD GROUPS, HEMOGLOBIN PHENOTYPES AND CLINICAL DISORDERS OF CONSANGUINEOUS YANSI POPULATION
Publication date :
06 November 2013
Journal title :
World Journal of Hematology
eISSN :
2218-6204
Volume :
2
Issue :
4
Pages :
109-114
Peer reviewed :
Peer reviewed
Available on ORBi :
since 23 November 2013

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