Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men
Zouaoui Boudjeltia, Karim; Delporte, Cédric; Van Antwerpen, Pierreet al.
[en] The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macrophages, can modify LDL (Mox-LDL) at the surface of endothelial cells. In addition we observed that the activation of the endothelial cells by angiotensin II amplifies this process. We suggested that induction of the NADPH oxidase complex was a major step in the oxidative process. Based on these data, we asked whether there was an independent association, in 121 patients, between NADPH oxidase modulators, such as angiotensin II, adiponectin, and levels of circulating Mox-LDL. Our observations suggest that the combination of blood angiotensin II, MPO
activity, and adiponectin explains, at least partially, serum Mox-LDL levels.
Research Center/Unit :
CORD - Centre de l'Oxygène, Recherche et Développement - ULiège
Disciplines :
Urology & nephrology
Author, co-author :
Zouaoui Boudjeltia, Karim; Université Libre de Bruxelles - ULB > Laboratory of Experimental Medicine (ULB 222 Unit)
Delporte, Cédric; Université Libre de Bruxelles - ULB > Laboratory of Pharmaceutical Chemistry and Analytical Platform
Van Antwerpen, Pierre; Université Libre de Bruxelles - ULB > Laboratory of Pharmaceutical Chemistry and Analytical Platform
Serteyn, Didier ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Moguilevsky, Nicole; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Technology Transfer Office,
Raes, Martine; Université Libre de Bruxelles - ULB > Laboratory of Biochemistry and Cellular Biology (NARILIS)
Vanhamme, Luc; Université Libre de Bruxelles - ULB > Institute for Molecular Biology and Medicine (IBMM),
Vanhaeverbeek, Michel; Université Libre de Bruxelles - ULB > Laboratory of Experimental Medicine (ULB 222 Unit)
Van Meerhaeghe, Alain; Université Libre de Bruxelles - ULB > Laboratory of Experimental Medicine (ULB 222 Unit)
Roumeguère, Thierry; Université Libre de Bruxelles - ULB > Department of Urology, Erasme University Hospital
Language :
English
Title :
Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men
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