Article (Scientific journals)
Oxidative stress-mediated iNKT-cell activation is involved in COPD pathogenesis.
Pichavant, M.; Remy, G.; Bekaert, Sandrine et al.
2013In Mucosal Immunology
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Abstract :
[en] Chronic obstructive pulmonary disease (COPD) is a major clinical challenge mostly due to cigarette smoke (CS) exposure. Invariant natural killer T (iNKT) cells are potent immunoregulatory cells that have a crucial role in inflammation. In the current study, we investigate the role of iNKT cells in COPD pathogenesis. The frequency of activated NKT cells was found to be increased in peripheral blood of COPD patients relative to controls. In mice chronically exposed to CS, activated iNKT cells accumulated in the lungs and strongly contributed to the pathogenesis. The detrimental role of iNKT cells was confirmed in an acute model of oxidative stress, an effect that depended on interleukin (IL)-17. CS extracts directly activated mouse and human dendritic cells (DC) and airway epithelial cells (AECs) to trigger interferongamma and/or IL-17 production by iNKT cells, an effect ablated by the anti-oxidant N-acetylcystein. In mice, this treatment abrogates iNKT-cell accumulation in the lung and abolished the development of COPD. Together, activation of iNKT cells by oxidative stress in DC and AECs participates in the development of experimental COPD, a finding that might be exploited at a therapeutic level.Mucosal Immunology advance online publication, 30 October 2013; doi:10.1038/mi.2013.75.
Disciplines :
Cardiovascular & respiratory systems
Biochemistry, biophysics & molecular biology
Author, co-author :
Pichavant, M.
Remy, G.
Bekaert, Sandrine ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path.
Le Rouzic, O.
Kervoaze, G.
Vilain, E.
Just, N.
Tillie-Leblond, I.
Trottein, F.
Cataldo, Didier  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path.
Gosset, P.
Language :
English
Title :
Oxidative stress-mediated iNKT-cell activation is involved in COPD pathogenesis.
Publication date :
2013
Journal title :
Mucosal Immunology
ISSN :
1933-0219
eISSN :
1935-3456
Publisher :
Nature Publishing Group, New York, United States - New York
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 November 2013

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