Article (Scientific journals)
Molecular epidemiology of norovirus infections in symptomatic and and asymptomatic children from Bobo Dioulasso, Burkina Faso
HUYNEN, Pascale; Mauroy, Axel; Martin, Caroline et al.
2013In Journal of Clinical Virology, 58, p. 515-521
Peer Reviewed verified by ORBi
 

Files


Full Text
Huynen_JCV_nov2013_NoV Burkina Faso.pdf
Publisher postprint (991.03 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Norovirus; Genotyping; Human; Africa; Epidemiology
Abstract :
[en] Background: Noroviruses (NoV) are a leading cause of gastroenteritis worldwide. Few epidemiologicaldata regarding the NoV strains circulating in African countries are available.Objectives: To determine the prevalence of NoV in Bobo Dioulasso (Burkina Faso) in both symptomaticand asymptomatic gastroenteritis patients.Study design: Patients both with and without gastro-intestinal disorders were selected. Clinical andepidemiological data, as well as stool samples, were collected through March to April 2011.NoV molecular detection (genogrouping and genotyping) and viral load quantification were also per-formed for all samples.Results: NoV were detected in 22.2% of the 418 collected stool samples (21.2% and 24.8% from the 293symptomatic patients (SP) and the 125 asymptomatic patients (ASP) respectively).Genogroup (G) distribution was 7.5%, 10.2% and 3.4% for GI, GII and both GI/GII respectively among SPand 12.0%, 11.2% and 1.6% for GI, GII and both GI/GII, respectively, among ASP.Average viral load values were higher in SP than in ASP for GI (p = 0.03) but not for GII.Phylogenic analysis showed a high degree of genotype diversity in SP and ASP. One recombinantGII.7/GII.6 sequence was, to the best of our knowledge, detected for the first time.Conclusions: This study enabled identification of the specific molecular epidemiology of NoV strains cir-culating in a representative country in Eastern Africa, and additionally showed that ASP could play animportant “reservoir” role. A high strain diversity was detected with a surprisingly high proportion ofNoV GI compared to the common genotypes usually reported in comparable epidemiological studies.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
HUYNEN, Pascale ;  Centre Hospitalier Universitaire de Liège - CHU > Microbiologie médicale
Mauroy, Axel ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Virologie vétérinaire et maladies virales animales
Martin, Caroline
Savadogo, Léon G. Blaise
BOREUX, Raphaël ;  Centre Hospitalier Universitaire de Liège - CHU > Microbiologie médicale
Thiry, Etienne ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Virologie vétérinaire et maladies virales animales
MELIN, Pierrette  ;  Centre Hospitalier Universitaire de Liège - CHU > Microbiologie médicale
De Mol, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
Molecular epidemiology of norovirus infections in symptomatic and and asymptomatic children from Bobo Dioulasso, Burkina Faso
Publication date :
November 2013
Journal title :
Journal of Clinical Virology
ISSN :
1386-6532
eISSN :
1873-5967
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
58
Pages :
515-521
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 October 2013

Statistics


Number of views
88 (16 by ULiège)
Number of downloads
2 (2 by ULiège)

Scopus citations®
 
46
Scopus citations®
without self-citations
45
OpenCitations
 
42

Bibliography


Similar publications



Contact ORBi