Poster (Scientific congresses and symposiums)
Effect of bio-sourced compounds on activation of immune cells in the view of to improve immunotherapy of malignant pleural mesothelioma
Hamaïdia, Malik; Cosse, Jean-Philippe; Willems, Luc
2013SFR Journée Codorcet
 

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Keywords :
Bio-sourced compounds; immunity; mesothelioma
Abstract :
[en] Glycans are macromolecules (O-glycosidic and N-glycosidic linkage of monosacharides) which can be extracted from various agricultural products (i.e. cellulose, lignin, starch, insect). Preliminary data indicate that glycans can stimulate inflammation without initiating an anti-inflammatory feedback loop. Notwithstanding, inhibition of immune response by anti-inflammatory cytokines is a major cause of cancer therapy failure in human. The goal of the project is to study the ability of glycans to modulate the functions of macrophages and dendritic cells in order to stimulate anti-tumor immune response. The project aims to assess this hypothesis in a high incidence cancer: Malignant Pleural Mesothelioma. Glycan extracts will be isolated from a variety of agroforestry resources and especially broadleaved trees of the different systems tested on the platform AgricultureIsLife (zones 1-3 : hedges, tree lines, agrisilviculture, short rotation coppice) and modified by physical, chemical, enzymatic or microbiotic approaches.
Research center :
laboratoire de biologie moleculaire et cellulaire Gembloux
Disciplines :
Agriculture & agronomy
Author, co-author :
Hamaïdia, Malik  ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Cosse, Jean-Philippe ;  Université de Liège - ULiège > GIGA-R : Epigénétique Cellulaire et Moléculaire
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Language :
English
Title :
Effect of bio-sourced compounds on activation of immune cells in the view of to improve immunotherapy of malignant pleural mesothelioma
Alternative titles :
[fr] Etude de l'effet de composés bio-sourcés sur l'activation des cellules immunitaires en vue d'améliorer l'immunothérapie du mésothéliome pleural malin
Publication date :
July 2013
Event name :
SFR Journée Codorcet
Event organizer :
Hélène Lacroix
Event place :
Beauvais, France
Event date :
du 02 juillet 2013 au 03 juillet 2013
Audience :
International
Available on ORBi :
since 11 October 2013

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