Black Africans, hepatitis C virus, antiviral therapy, genotype 4.
Abstract :
[en] Aim : To compare responses to therapy of Black African (BA)
and non-Black African (non- BA) patients with hepatitis C virus
genotype 4 (HCV-4) residing in Belgium.
Methods : In this retrospective multicenter study, 473 patients
with HCV-4 were selected from databases at 7 Belgian centers ;
209 treatment-naïve patients (154 BA) had received treatment with
peg-interferon (peg-IFN) plus ribavirin (RBV) and were included
in the study.
Results : There was a greater percentage of female patients in the
BA group than in the non- BA group ; BA patients were also older,
had a greater body mass index, and more frequently had abnormal
glucose metabolism. The route of contamination was more frequently
unknown in BA than in non-BA patients and BA patients
had more HCV-4 subtypes. There were no differences in other demographic
factors between the groups. Sustained viral response
(SVR) and complete early viral response rates were significantly
lower and relapse rates significantly higher in BA than in non-BA
patients. There were no differences between groups in rates of dose
modification or in drug tolerance.
Conclusion : In our cohort, treatment-naïve BA patients with
HCV-4 who were treated with peg-IFN and ribavirin had a much
lower SVR rate than treatment-naïve non-BA patients with HCV-
4 who were treated with peg-IFN and ribavirin, and a higher
relapse
rate, possibly related to a weaker response to interferonbased
therapy. Treatment may need to be adapted in this population.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Nkuize, M
Mulkay, JP
Adler, M
Lasser, L
Michielsen, P
de Galocsy, C
Assene, C
DELWAIDE, Jean ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Language :
English
Title :
Response of Black African patients with hepatitis C virus genotype 4 to treatment with peg-interferon and ribavirin
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