Article (Scientific journals)
Esterification of vertebrate like steroids in molluscs: A target of endocrine disruptors?
Giusti, Arnaud; Joaquim-Justo, Célia
2013In Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology, 158 (4), p. 187-198
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Keywords :
Endocrine Disrupting Chemicals; Molluscs; Steroid esterification; Steroid metabolism; androgen; oestrogen; Organotin
Abstract :
[en] Alterations of the reproductive organs of gastropod molluscs exposed to pollutants have been reported in natural populations for more than 40 years. In some cases these impacts have been linked to exposure to endocrine disrupting chemicals (EDCs), which are known to induce adverse impacts on vertebrates, mainly by direct binding to steroid receptors or by altering hormone synthesis. Investigations on the mechanisms of action of endocrine disruptors in molluscs show that EDCs induce modifications of endogenous titres of androgens (e.g., testosterone, androstenedione) and oestrogens (e.g., 17ß-oestradiol). Alterations of the activity of enzymes related to steroid metabolism (i.e., cytochrome P450 aromatase, acyltransferases) are also often observed. In bivalves and gastropods, fatty acid esterification of steroids might constitute the major regulation of androgen and oestrogen homeostasis. The present review indicates that metabolism of steroid hormones to fatty acid esters might be a target of synthetic EDCs. Alterations of this process would impact the concentrations of free, potentially bioactive, form of steroids.
Disciplines :
Environmental sciences & ecology
Author, co-author :
Giusti, Arnaud ;  Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Ecologie animale et écotoxicologie
Joaquim-Justo, Célia ;  Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Ecologie animale et écotoxicologie
Language :
English
Title :
Esterification of vertebrate like steroids in molluscs: A target of endocrine disruptors?
Publication date :
November 2013
Journal title :
Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
ISSN :
0742-8413
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
158
Issue :
4
Pages :
187-198
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
FRFC - Fonds de la Recherche Fondamentale Collective [BE]
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