[en] Human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) are two closely related deltaretroviruses inducing hematological diseases in human and ruminants. HTLV-1 infects about 25 million subjects worldwide and causes Adult T-cell leukemia-lymphoma (ATLL) or HAM/TSP (HTLV-induced myelopathy - tropical spastic paraparesis). BLV is the etiological agent of enzootic bovine leukemia. HTLV-1 and BLV have developed strategies to subvert hosts' immune surveillance. Understanding these mechanisms has allowed development of novel therapeutic approaches.
Disciplines :
Oncology
Author, co-author :
Willems, Luc ; Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Language :
English
Title :
Transformation by deltaretroviruses: mechanisms and therapies
Publication date :
2012
Journal title :
Proceedings of the Belgian Royal Academies of Medicine
ISSN :
2034-7626
Publisher :
Koninklijke Academie voor Geneeskunde van België, Académie Royale de Médecine de Belgique., Bruxelles, Belgium
Volume :
1
Pages :
157-165
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique
Commentary :
This work was supported by the “Fonds National de la Recherche Scientifique” (FNRS), the Télévie, the Belgian Foundation against Cancer, the Sixth Research Framework Programme of the European Union (project INCA LSHC-CT-2005-018704), the “Neoangio” excellence program and the “Partenariat Public Privé” PPP INCA of the “Direction générale des Technologies, de la Recherche et de l’Energie/DG06” of the Walloon government, the “Action de Recherche Concertée Glyvir” of the “Communauté française de Belgique”, the “Fonds spéciaux pour la Recherche” of the University of Liège (ULg), the Synbiofor program of GxABT (ULg), the “Centre anticancéreux près ULg” (CAC), the “Plan Cancer” of the “Service Public Fédéral” and the Interuniversity Attraction Poles (IAP) Phase VII BELVIR.
