Reference : Glycine Receptor α2 Subunit Activation Promotes Cortical Interneuron Migration
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Glycine Receptor α2 Subunit Activation Promotes Cortical Interneuron Migration
Avila Macaya, Ariel Salvatore mailto [Université de Liège - ULiège > > > Form. doc. sc. bioméd. & pharma.]
Vidal, Pia M [Universiteit Hasselt - UH > Morphology > > >]
Dear, T Neil [University of Leeds > > > >]
Harvey, Robert J [University College London - UCL > UCL Shool of Pharmacy > > >]
Rigo, Jean-Michel [Universiteit Hasselt - UH > Cell Physiology > > >]
Nguyen, Laurent mailto [Université de Liège - ULiège > > GIGA - Neurosciences >]
Cell Reports
Yes (verified by ORBi)
[en] Interneuron ; glycine receptors ; GlyR ; time-lapse ; Development ; migration ; patch-clamp ; glycine
[en] Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration. Taken together, our data highlight the molecular events triggered by GlyR α2 activation that control cortical tangential migration during embryogenesis.
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