Glycine Receptor α2 Subunit Activation Promotes Cortical Interneuron Migration

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Keywords :

Interneuron; glycine receptors; GlyR; time-lapse; Development; migration; patch-clamp; glycine

Abstract :

[en] Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration. Taken together, our data highlight the molecular events triggered by GlyR α2 activation that control cortical tangential migration during embryogenesis.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Avila Macaya, Ariel Salvatore ; Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.

Vidal, Pia M; Universiteit Hasselt - UH > Morphology

Dear, T Neil; University of Leeds

Harvey, Robert J; University College London - UCL > UCL Shool of Pharmacy

Rigo, Jean-Michel; Universiteit Hasselt - UH > Cell Physiology

Nguyen, Laurent ; Université de Liège - ULiège > GIGA - Neurosciences

Language :

English

Title :

Glycine Receptor α2 Subunit Activation Promotes Cortical Interneuron Migration

Publication date :

29 August 2013

Journal title :

Cell Reports

eISSN :

2211-1247

Publisher :

Elsevier

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.cell.com/cell-reports/fulltext/S2211-1247(13)00378-1?switch=standard
http://reflexions.ulg.ac.be/RecepteurGlycine

Available on ORBi :

since 16 August 2013

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