From DNA sequence analysis to modeling replication in the human genome

[en] We explore the large-scale behavior of nucleotide compositional strand asymmetries along hum chromosomes. As we observe for 7 of 9 origins of replication experimentally identified so far, the (TA GC) skew displays rather sharp upward jumps, with a linear decreasing profile in between two successi jumps. We present a model of replication with well positioned replication origins and random terminatio that accounts for the observed characteristic serrated skew profiles. We succeed in identifying 287 pairs putative adjacent replication origins with an origin spacing 12 Mbp that are likely to correspond replication foci observed in interphase nuclei and recognized as stable structures that persist througho subsequent cell generations.

Disciplines :

Mathematics

Author, co-author :

Brodie of Brodie, E. B.

Nicolay, Samuel ; Université de Liège - ULiège > Département de mathématique > Analyse - Analyse fonctionnelle - Ondelettes

Touchon, M.

Audit, B.

d'Aubenton-Carafa, Y.

Thermes, C.

Arneodo, Alain

Language :

English

Title :

From DNA sequence analysis to modeling replication in the human genome

Publication date :

2005

Journal title :

Physical Review Letters

ISSN :

0031-9007

eISSN :

1079-7114

Publisher :

American Physical Society, Ridge, United States - New York

Volume :

Pages :

248103

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 January 2010

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