Article (Scientific journals)
Hematopoietic cell transplantation: five decades of progress.
Baron, Frédéric; Storb, Rainer; Little, Marie-Terese
2003In Archives of Medical Research, 34 (6), p. 528-44
Peer Reviewed verified by ORBi
 

Files


Full Text
ArcMedRes22.9.03.final2.baron et al.2003.mtl.doc
Author preprint (199.68 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Animals; Graft vs Host Disease; HLA Antigens/immunology/metabolism; Hematologic Diseases/therapy; Hematopoietic Stem Cell Transplantation/history; History, 20th Century; History, 21st Century; Humans; Transplantation Chimera; Transplantation Conditioning; Transplantation Immunology; Transplantation, Homologous/history
Abstract :
[en] During the past 50 years, the role of allogeneic hematopoietic cell transplantation (HCT) has changed from a desperate therapeutic maneuver plagued by apparently insurmountable complications to a curative treatment modality for thousands of patients with hematologic diseases. Now, cure rates following human leukocyte antigen (HLA) allogeneic HCT with matched siblings exceed 85% for some otherwise lethal diseases, such as chronic myeloid leukemia, aplastic anemia, or thalassemia. In addition, the recent development of non-myeloablative conditioning and stem cell transplantation has opened the way to include elderly patients with a wide variety of hematologic malignancies. Further progress in adoptive transfer of T cell populations with relative tumor specificity would make the transplant procedure more effective and would extend the use of allogeneic HCT for treatment of non-hematopoietic malignancies.
Disciplines :
Hematology
Author, co-author :
Baron, Frédéric  ;  Université de Liège - ULiège > Département des sciences cliniques > GIGA-R : Hématologie - Département des sciences cliniques
Storb, Rainer
Little, Marie-Terese
Language :
English
Title :
Hematopoietic cell transplantation: five decades of progress.
Publication date :
2003
Journal title :
Archives of Medical Research
ISSN :
0188-4409
Publisher :
Elsevier Science, New York, United States - New York
Volume :
34
Issue :
6
Pages :
528-44
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 June 2013

Statistics


Number of views
150 (1 by ULiège)
Number of downloads
357 (0 by ULiège)

Scopus citations®
 
40
Scopus citations®
without self-citations
37
OpenCitations
 
42

Bibliography


Similar publications



Contact ORBi