Iung B, Baron G, Butchart EG, et al. A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on valvular heart disease. Eur Heart J 2003;24:1231-43.
Iung B, Gohlke-Bärwolf C, Tornos P, et al. Recommendations on the management of the asymptomatic patient with valvular heart disease. Eur Heart J 2002;23:1253-66.
Carabello BA, Chatterjee K, de Leon AC Jr, et al. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease. J Am Coll Cardiol 2006;48:e1-148.
Das P, Rimington H, Smeeton N, et al. Determinants of symptoms and exercise capacity in aortic stenosis: a comparison of resting haemodynamics and valve compliance during dobutamine stress. Eur Heart 2003;24:1254-62.
Das P, Rimington H, Chambers J. Exercise testing to stratify risk in aortic stenosis Eur Heart J 2005;26:1309-13. ▶ Important study concerning the role of exercise testing in aortic stenosis.
Amato MCM, Moffa PJ, Werner KE, et al. Treatment decision in asymptomatic aortic valve stenosis: role of exercise testing. Heart 2001;86:381-6.
Alborino D, Hoffmann JL, Fournet PC, et al. Value of exercise testing to evaluate the indication for surgery in asymptomatic patients with valvular aortic stenosis. J Heart Valve Dis 2002;11:204-9.
Lancellotti P, Lebois F, Simon M, et al. Prognostic importance of quantitative exercise Doppler echocardiography in asymptomatic valvular aortic stenosis. Circulation 2005;112(9 Suppl):I377-82.
Lange RA, Hillis LD. Dobutamine stress echocardiography in patients with low-gradient aortic stenosis. Circulation 2006;113:1718-20.
Monin JL, Quere JP, Monchi M, et al. Low-gradient aortic stenosis: operative risk stratification and predictors for long-term outcome: a multicenter study using dobutamine stress hemodynamics. Circulation 2003;108:319-24. ▶ Largest multicentre study defining the role of dobutamine stress echocardiography in low gradient aortic stenosis.
Nishimura RA, Grantham JA, Connolly HM, et al. Low-output, low-gradient aortic stenosis in patients with depressed left ventricular systolic function: the clinical utility of the dobutamine challenge in the catheterization laboratory. Circulation 2002;106:809-13.
deFilippi CR, Willett DL, Brickner ME, et al. Usefulness of dobutamine echocardiography in distinguishing severe from non-severe valvular aortic stenosis in patients with depressed left ventricular function and low transvalvular gradients. Am J Cardiol 1995;75:191-4.
Quere J-P, Monin J-L, Levy F, et al. Influence of preoperative left ventricular contractile reserve on postoperative ejection fraction in low-gradient aortic stenosis. Circulation 2006;113:1738-44.
Wahi S, Haluska B, Pasquet A, et al. Exercise echocardiography predicts development of left ventricular dysfunction in medically and surgically treated patients with asymptomatic severe aortic regurgitation. Heart 2000;84:606-14.
Vinereanu D, Ionescu AA, Fraser AG. Assessment of left ventricular long axis contraction can detect early myocardial dysfunction in asymptomatic patients with severe aortic regurgitation. Heart 2001;85:30-6.
Cheitlin MD. Stress echocardiography in mitral stenosis: when is it useful? J Am Coll Cardiol 2004;43:402-4.
Reis G, Motta MS, Barbosa MM, et al. Dobutamine stress echocardiography for noninvasive assessment and risk stratification of patients with rheumatic mitral stenosis. J Am Coll Cardiol 2004;43:393-401.
Enriquez-Sarano M, Avierinos JF, Messika-Zeitoun D, et al. Quantitative determinants of the outcome of asymptomatic mitral regurgitation. N Engl J Med 2005;352:875-83. ▶ Important study demonstrating the importance of quantitation of mitral regurgitation.
Leung DY, Griffin BP, Stewart WJ, et al. Left ventricular function after valve repair for chronic mitral regurgitation: predictive value of preoperative assessment of contractile reserve by exercise echocardiography. J Am Coll Cardiol 1996;28:1198-205. ▶ Largest single centre study defining the role of post-exercise echocardiography in organk mitral regurgitation.
Lee R, Haluska B, Leung DY, et al. Functional and prognostic implications of left ventricular contractile reserve in patients with asymptomatic severe mitral regurgitation. Heart 2005;91:1407-12.
Levine RA, Schwammenthal E. Ischemic mitral regurgitation on the threshold of a solution: from paradoxes to unifying concepts. Circulation 2005;112:745-58. ▶ Excellent review of ischaemic mitral regurgitation.
McCully RB, Enriquez-Sarano M, Tajik AJ, et al. Overestimation of severity of ischemic/functional mitral regurgitation by color Doppler jet area. Am J Cardiol 1994;74:790-3.
Lebrun F, Lancellotti P, Piérard LA. Quantitation of functional mitral regurgitation during bicycle exercise in patients with heart failure. J Am Coll Cardiol 2001;38:1685-92. ▶ First study validating quantitation of mitral regurgitation during exercise.
Grigioni F, Enriquez-Sarano M, Zehr KJ, et al. Ischemic mitral regurgitation. Long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation 2001;103:1759-64.
Lancellotti P, Lebrun F, Piérard LA. Determinants of exercise-induced changes in mitral regurgitation in patients with coronary artery disease and left ventricular dysfunction. J Am Coll Cardiol 2003;42:1921-8.
Lancellotti P, Stainier PY, Lebois F, et al. Effects of dynamic changes in left ventricular synchronicity on dynamic mitral regurgitation. Am J Cardiol 2005;96:1304-7.
Piérard LA, Lancellotti P. Left ventricular dyssynchrony and dynamic functional mitral regurgitation: relationship or association? Eur Heart J 2006;27:638-40.
Piérard LA, Lancellotti P. Dyspnea and stress testing. N Engl J Med 2006;354:871-3.
Piérard LA, Lancellotti P. The role of ischemic mitral regurgitation in the pathogenesis of acute pulmonary edema. N Engl J Med 2004;351:1627-34. ▶ Clinical study indicating that acute pulmonary oedema can be produced by dynamic ischaemic mitral regurgitation.
Lancellotti P, Troisfontaines P, Toussaint A-C, et al. Prognostic importance of exercise-induced changes in mitral regurgitation in patients with chronic ischemic left ventricular dysfunction. Circulation 2003;108:1713-7.
Lancellotti P, Gérard P, Piérard L. Long term outcome of patients with heart failure and dynamic mitral regurgitation. Eur Heart J 2005;26:1528-32. ▶ Dynamic ischaemic mitral regurgitation predicts both increased mortality and decompensated heart failure.
Breithardt OA, Sinha AM, Schwammenthal E, et al. Acute effects of cardiac resynchronization therapy on functional mitral regurgitation in advanced systolic heart failure. J Am Coll Cardiol 2003;41:765-70.
Lancellotti P, Mélon P, Sakalihasan N, et al. Effects of cardiac resynchronization therapy on functional mitral regurgitation in heart failure. Am J Cardiol 2004;94:462-5.
