Toxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage i to III breast cancer (EORTC trial 22922/10925)
Matzinger et al. - 2010 - Toxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage I to III breast cancer (EORTC trial 2292210925). - Acta Oncol.pdf
Adult; Aged; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Heart; Humans; Lymphatic Metastasis; Mastectomy; Middle Aged; Neoplasm Staging; Pulmonary Fibrosis; Radiotherapy; Severity of Illness Index
Abstract :
[en] Introduction. The EORTC 22922/10925 trial investigated the potential survival benefit and toxicity of elective irradiation of the internal mammary and medial supraclavicular (IM-MS) nodes Accrual completed in January 2004 and first results are expected in 2012. We present the toxicity reported until year 3 after treatment. Patients and methods. At each visit, toxicity was reported but severity was not graded routinely. Toxicity rates and performance status (PS) changes at three years were compared by χ2 tests and logistic regression models in all the 3 866 of 4 004 patients eligible to the trial who received the allocated treatment. Results. Only lung (fibrosis; dyspnoea; pneumonitis; any lung toxicities) (4.3% vs. 1.3%; p < 0.0001) but not cardiac toxicity (0.3% vs. 0.4%; p = 0.55) significantly increased with IM-MS treatment. No significant worsening of the PS was observed (p = 0.79), suggesting that treatment-related toxicity does not impair patient's daily activities. Conclusions. IM-MS irradiation seems well tolerated and does not significantly impair WHO PS at three years. A follow-up period of at least 10 years is needed to determine whether cardiac toxicity is increased after radiotherapy.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Matzinger, O.; European Organisation for Research and Treatment of Cancer (EORTC), Headquarters, Brussels, Belgium, Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
Heimsoth, I.; Department of Radiation Oncology, University Medical Centre Utrecht, Utrecht, Netherlands
Poortmans, P.; Department of Radiation Oncology, Dr. Bernard Verbeeten Institut, Tilburg, Netherlands
Collette, L.; European Organisation for Research and Treatment of Cancer (EORTC), Headquarters, Brussels, Belgium
Struikmans, H.; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, Netherlands
Bogaert, W. V. D.; Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium
Fourquet, A.; Department of Radiation Oncology, Institut Curie, Paris, France
Bartelink, H.; Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands
Ataman, F.; Department of Radiation Oncology, Süleyman Demirel University, Isparta, Turkey
GULYBAN, Akos ; Centre Hospitalier Universitaire de Liège - CHU > Radiothérapie
Pierart, M.; European Organisation for Research and Treatment of Cancer (EORTC), Headquarters, Brussels, Belgium
Tienhoven, G. V.; Department of Radiation Oncology, Academic Medical Centre, Amsterdam, Netherlands
Language :
English
Title :
Toxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage i to III breast cancer (EORTC trial 22922/10925)
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