Article (Scientific journals)
Quality assurance in the 22991 EORTC ROG trial in localized prostate cancer: Dummy run and individual case review
Matzinger, O.; Poortmans, P.; Giraud, J.-Y. et al.
2009In Radiotherapy and Oncology, 90 (3), p. 285-290
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Matzinger et al. - 2009 - Quality assurance in the 22991 EORTC ROG trial in localized prostate cancer dummy run and individual case review. - Radiother Oncol.pdf
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Keywords :
Dummy run; Individual case review; Prostate cancer; Quality assurance; Radiotherapy; Randomized trial; Androgen Antagonists; Combined Modality Therapy; Disease-Free Survival; Humans; Male; Prostatic Neoplasms; Quality Assurance, Health Care; Radiotherapy Dosage; Radiotherapy, Conformal; Radiotherapy, Intensity-Modulated; Research Design
Abstract :
[en] Introduction: EORTC trial 22991 was designed to evaluate the addition of concomitant and adjuvant short-term hormonal treatments to curative radiotherapy in terms of disease-free survival for patients with intermediate risk localized prostate cancer. In order to assess the compliance to the 3D conformal radiotherapy protocol guidelines, all participating centres were requested to participate in a dummy run procedure. An individual case review was performed for the largest recruiting centres as well. Materials and methods: CT-data of an eligible prostate cancer patient were sent to 30 centres including a description of the clinical case. The investigator was requested to delineate the volumes of interest and to perform treatment planning according to the protocol. Thereafter, the investigators of the 12 most actively recruiting centres were requested to provide data on five randomly selected patients for an individual case review. Results: Volume delineation varied significantly between investigators. Dose constraints for organs at risk (rectum, bladder, hips) were difficult to meet. In the individual case review, no major protocol deviations were observed, but a number of dose reporting problems were documented for centres using IMRT. Conclusions: Overall, results of this quality assurance program were satisfactory. The efficacy of the combination of a dummy run procedure with an individual case review is confirmed in this study, as none of the evaluated patient files harboured a major protocol deviation. Quality assurance remains a very important tool in radiotherapy to increase the reliability of the trial results. Special attention should be given when designing quality assurance programs for more complex irradiation techniques. © 2008 Elsevier Ireland Ltd. All rights reserved.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Matzinger, O.;  EORTC Headquarters, Belgium, Centre Hospitaliuer Universitaire Vaudois, Department of Radiation Oncology, Lausanne, Switzerland
Poortmans, P.;  Dr. Bernard Verbeeten Institute, Tilburg, Netherlands
Giraud, J.-Y.;  Centre Hospitalier Universitaire de Grenoble, Department of Radiation Oncology, Grenoble, France
Maingon, P.;  Centre Georges-Francois Leclerc, Department of Radiation Oncology, Dijon, France
Budiharto, T.;  EORTC Headquarters, Belgium
van den Bergh, A. C. M.;  University Medical Centre Groningen, Department of Radiation Oncology, Groningen, Netherlands
Davis, J. B.;  University Hospital, Department of Radiation Oncology, Zurich, Switzerland
Musat, E.;  Institute Gustave Roussy, Department of Radiation Oncology, Villejuif, France
Ataman, F.;  EORTC Headquarters, Belgium
Huyskens, D. P.;  7Sigma, QA-team in Radiotherapy Physics, Belgium
GULYBAN, Akos ;  Centre Hospitalier Universitaire de Liège - CHU > Radiothérapie
Bolla, M.;  Centre Hospitalier Universitaire de Grenoble, Department of Radiation Oncology, Grenoble, France
Language :
English
Title :
Quality assurance in the 22991 EORTC ROG trial in localized prostate cancer: Dummy run and individual case review
Publication date :
2009
Journal title :
Radiotherapy and Oncology
ISSN :
0167-8140
eISSN :
1879-0887
Publisher :
Elsevier Scientific, Limerick, Ireland
Volume :
90
Issue :
3
Pages :
285-290
Peer reviewed :
Peer Reviewed verified by ORBi
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