Article (Scientific journals)
EORTC Radiation Oncology Group quality assurance platform: Establishment of a digital central review facility
Fairchild, A.; Aird, E.; Fenton, P. A. et al.
2012In Radiotherapy and Oncology, 103 (3), p. 279-286
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Keywords :
Central review; Clinical trial; Platform; Quality assurance; Radiotherapy; Internet; Computer Communication Networks; Europe; Humans; Information Storage and Retrieval; Multicenter Studies as Topic; Quality Assurance, Health Care; Radiation Oncology; Radiology Information Systems; Software
Abstract :
[en] Objective: Quality assurance (QA) in clinical trials is essential to ensure treatment is safely and effectively delivered. As QA requirements have increased in complexity in parallel with evolution of radiation therapy (RT) delivery, a need to facilitate digital data exchange emerged. Our objective is to present the platform developed for the integration and standardization of QART activities across all EORTC trials involving RT. Methods: The following essential requirements were identified: secure and easy access without on-site software installation; integration within the existing EORTC clinical remote data capture system; and the ability to both customize the platform to specific studies and adapt to future needs. After retrospective testing within several clinical trials, the platform was introduced in phases to participating sites and QART study reviewers. Results: The resulting QA platform, integrating RT analysis software installed at EORTC Headquarters, permits timely, secure, and fully digital central DICOM-RT based data review. Participating sites submit data through a standard secure upload webpage. Supplemental information is submitted in parallel through web-based forms. An internal quality check by the QART office verifies data consistency, formatting, and anonymization. QART reviewers have remote access through a terminal server. Reviewers evaluate submissions for protocol compliance through an online evaluation matrix. Comments are collected by the coordinating centre and institutions are informed of the results. Conclusions: This web-based central review platform facilitates rapid, extensive, and prospective QART review. This reduces the risk that trial outcomes are compromised through inadequate radiotherapy and facilitates correlation of results with clinical outcomes. © 2012 Elsevier Ireland Ltd. All rights reserved.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Fairchild, A.;  EORTC Headquarters, Brussels, Belgium, Cross Cancer Institute, Edmonton, Canada
Aird, E.;  Mount Vernon Hospital, Northwood Middlesex, United Kingdom
Fenton, P. A.;  Southampton University Hospital NHS Trust, United Kingdom
Gregoire, V.;  Université Catholique de Louvain, Brussels, Belgium
GULYBAN, Akos ;  Centre Hospitalier Universitaire de Liège - CHU > Radiothérapie
Lacombe, D.;  EORTC Headquarters, Brussels, Belgium
Matzinger, O.;  Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
Poortmans, P.;  Institute Verbeeten, Tilburg, Netherlands
Ruyskart, P.;  EORTC Headquarters, Brussels, Belgium
Weber, D. C.;  Geneva University Hospital, Switzerland
Hurkmans, C. W.;  Catharina Hospital, Eindhoven, Netherlands
Language :
English
Title :
EORTC Radiation Oncology Group quality assurance platform: Establishment of a digital central review facility
Publication date :
2012
Journal title :
Radiotherapy and Oncology
ISSN :
0167-8140
eISSN :
1879-0887
Publisher :
Elsevier Scientific, Limerick, Ireland
Volume :
103
Issue :
3
Pages :
279-286
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 June 2013

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