[en] Different methods for analyzing the sensitivity of the direct signal transduction pathway of receptor-induced apoptosis to parameter changes are presented. Apoptosis is a form of programmed cell death, removing unwanted cells within multicellular organisms to maintain a proper balance between cell reproduction and death. The results indicate the importance of controlling activated caspases by direct inhibition to prevent apoptosis. A misregulation of IAP molecules, one of the main inhibitors, appears to be especially critical. The results indicate how an increased production of this molecule promotes survival and might promote cancer progression, while a reduced degradation might not, thereby providing insight of potential pharmaceutical relevance and also stimulating experimental verification. The different engineering methods applied, nicely complement each other to provide valuable insight into this important process. Because IAPs, among others, are also an important connection to other signaling pathways, the results will enable a more efficient extension of the current model. This is outlined at the example of tumor necrosis factor induced signaling pathways
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Eissing, Thomas; University of Stuttgart > Institute for Systems Theory and Automatic Control
Waldherr, Steffen; University of Stuttgart > Institute for Systems Theory and Automatic Control
Gondro, Cedric; University of New England > Institute for Genetics and Bioinformatics
Bullinger, Eric ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Méthodes computationnelles pour la biologie systémique
Sawodny, Oliver
Allgöwer, Frank
Scheurich, Peter
Sauter, Thomas
Language :
English
Title :
Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during tumor necrosis factor stimulation
Publication date :
2006
Event name :
IEEE Conference on Control Applications
Event place :
MunichProc. of the IEEE Conference on Control Applications, Germany
Event date :
4–6 October 2006
Audience :
International
Main work title :
Proc. of the 2006 IEEE Conference on Control Applications
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