[en] Reduced vitamins K are acting as cofactors of glutamic carboxylation of procoagulant factors (II, VII, IX and X). The reduction of these vitamins is inhibited by oral anticoagulants. The response to antivitamins K is individual and may change during the treatment of a patient. The determinations of plasmatic vitamin K and acenocoumarol may help to explain the mechanism of a resistance to the anticoagulant therapy. Quantifications of vitamin K1 are realized after liquid-liquid extraction with liquid chromatography and fluorescence detection after post-column reduction. For acenocoumarol, plasma concentration is measured, after liquid-liquid extraction, by liquid chromatograph, with ion trap mass spectrometer detector.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Gougnard, Thierry
Charlier, Corinne ; Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique
David, Jean-Louis ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Plomteux, Guy ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
French
Title :
Concentrations plasmatiques de la vitamine K1 et de l'acenocoumarol en fonction du temps de quick (I.N.R.)
Alternative titles :
[en] Plasma Concentrations of Vitamin K1 and Acenocoumarol Related to International Normalized Ratios
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