Metabolically Obese Normal Weight; Visceral adipose tissue; Obesity; Metabolic syndrome
Abstract :
[en] Around 30 to 50% of obese subjects are “metabolically normal” (MHO) whereas numerous nonobese subjects are “metabolically abnormal”. The distribution and function of adipose deposits seem to play a crucial role in explaining this apparent paradox. The aim of this first article is to describe the clinical and biological characteristics that lead to the diagnosis of MHO, attempt to discover the etiopathogenesis of this syndrome and analyze the underlying pathophysiological mechanisms and, finally, to assess the prevalence of the MHO phenotype, which may vary according to the definition used and the population studied. [fr] Environ 30 à 50 % des sujets obèses sont « métaboliquement normaux » (MHO metabolically healthy, but obese) alors qu’inversement, nombre de sujets non obèses sont « métaboliquement anormaux ». La topographie et la fonction des dépôts graisseux semblent jouer un rôle déterminant pour expliquer cet apparent paradoxe. Ce premier article vise à présenter les éléments conduisant au diagnostic du phénotype MHO, à tenter d’en cerner l’étiopathogénie et de mieux comprendre sa physiopathologie et, enfin, à analyser la prévalence de ce syndrome, quelque peu différente en fonction de la définition retenue et de la population étudiée.
Paquot, Nicolas ; Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
Sujets « métaboliquement sains », bien qu’obèses. Première partie: diagnostic, physiopathologie et prévalence
Alternative titles :
[en] Metabolically healthy, but obese subjects. First part: definition, pathophysiology and prevalence
Publication date :
March 2009
Journal title :
Obésité: Revue Francophone pour la Recherche Clinique, la Prévention et la Prise en Charge de l'Obésité
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