[en] The cytoplasmic/nuclear relocalization of beta-catenin and ZO-1 from the adherens and tight junctions are common processes of the epithelial-mesenchymal transition (EMT) associated with tumor invasion. Data are now accumulating to demonstrate that these molecules, which shuttle between the plasma membrane and the nucleus or the cytosol, are involved in signaling pathways, and contribute to the regulation of genes such as vimentin or matrix metalloproteinase-14 which are turned on during EMT. Copyright (c) 2007 S. Karger AG, Basel.
Balda, M.S., Matter, K., The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression (2000) EMBO J, 19, pp. 2024-2033
Balda, M.S., Garrett, M.D., Matter, K., The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density (2003) J Cell Biol, 160, pp. 423-432
Balda, M.S., Matter, K., Epithelial cell adhesion and the regulation of gene expression (2003) Trends Cell Biol, 13, pp. 310-318
Bindels, S., Mestdagt, M., Vandewalle, C., Jacobs, N., Volders, L., Noel, A., van Roy, F., Gilles, C., Regulation of vimentin by SIP1 in human epithelial breast tumor cells (2006) Oncogene, 25, pp. 4975-4985
Brabletz, T., Jung, A., Dag, S., Hlubek, F., Kirchner, T., Beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer (1999) Am J Pathol, 155, pp. 1033-1038
Brembeck, F.H., Rosario, M., Birchmeier, W., Balancing cell adhesion and Wnt signaling, the key role of beta-catenin (2006) Curr Opin Genet Dev, 16, pp. 51-59
Egeblad, M., Werb, Z., New functions for the matrix metalloproteinases in cancer progression (2002) Nat Rev Cancer, 2, pp. 161-174
Gilles, C., Piette, J., Peter, W., Fusenig, N.E., Foidart, J.M., Differentiation ability and oncogenic potential of HPV-33 - and HPV-33+ ras-transfected keratinocytes (1994) Int J Cancer, 58, pp. 847-854
Gilles, C., Polette, M., Piette, J., Birembaut, P., Foidart, J.M., Epithelial-to-mesenchymal transition in HPV-33-transfected cervical keratinocytes is associated with increased invasiveness and expression of gelatinase A (1994) Int J Cancer, 59, pp. 661-666
Gilles, C., Polette, M., Piette, J., Delvigne, A.C., Thompson, E.W., Foidart, J.M., Birembaut, P., Vimentin expression in cervical carcinomas: Association with invasive and migratory potential (1996) J Pathol, 180, pp. 175-180
Gilles, C., Polette, M., Piette, J., Munaut, C., Thompson, E.W., Birembaut, P., Foidart, J.M., High level of MT-MMP expression is associated with invasiveness of cervical cancer cells (1996) Int J Cancer, 65, pp. 209-213
Gilles, C., Polette, M., Zahm, J.M., Tournier, J.M., Volders, L., Foidart, J.M., Birembaut, P., Vimentin contributes to human mammary epithelial cell migration (1999) J Cell Sci, 112, pp. 4615-4625
Gilles, C., Polette, M., Coraux, C., Tournier, J.M., Meneguzzi, G., Munaut, C., Volders, L., Foidart, J.M., Contribution of MT1-MMP and of human laminin-5 gamma2 chain degradation to mammary epithelial cell migration (2001) J Cell Sci, 114, pp. 2967-2976
Gilles, C., Polette, M., Mestdagt, M., Nawrocki-Raby, B., Ruggeri, P., Birembaut, P., Foidart, J.M., Transactivation of vimentin by betacatenin in human breast cancer cells (2003) Cancer Res, 63, pp. 2658-2664
Gilles, C., D. Newgreen, H. Sato, E.W. Thompson (2004) Matrix metalloproteases and epithelial-to-mesenchymal transition: implications for carcinoma metastasis
in Savagner, P. (ed): Rise and Fall of Epithelial Phenotype. Georgetown, Eurekah.com and Kluwer Academic/Plenum Publishers, chap 2
Gonzalez-Mariscal, L., Betanzos, A., Nava, P., Jaramillo, B.E., Tight junction proteins (2003) Prog Biophys Mol Biol, 81, pp. 1-44
Gottardi, C.J., Arpin, M., Fanning, A.S., Louvard, D., The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts (1996) Proc Natl Acad Sci USA, 93, pp. 10779-10784
Harris, T.J., Peifer, M., Decisions, decisions: Beta-catenin chooses between adhesion and transcription (2005) Trends Cell Biol, 15, pp. 234-237
Hendrix, M.J., Seftor, E.A., Seftor, R.E., Trevor, K.T., Experimental co-expression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasive behavior (1997) Am J Pathol, 150, pp. 483-495
Huber, M.A., Kraut, N., Beug, H., Molecular requirements for epithelial-mesenchymal transition during tumor progression (2005) Curr Opin Cell Biol, 17, pp. 548-558
Ikenouchi, J., Matsuda, M., Furuse, M., Tsukita, S., Regulation of tight junctions during the epithelium-mesenchyme transition: Direct repression of the gene expression of claudins/occludin by Snail (2003) J Cell Sci, 116, pp. 1959-1967
Levy, L., Neuveut, C., Renard, C.A., Charneau, P., Branchereau, S., Gauthier, F., Van Nhieu, J.T., Buendia, M.A., Transcriptional activation of interleukin-8 by beta-catenin-Tcf4 (2002) J Biol Chem, 277, pp. 42386-42393
Lochter, A., Galosy, S., Muschler, J., Freedman, N., Werb, Z., Bissell, M.J., Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells (1997) J Cell Biol, 139, pp. 1861-1872
Marchenko, G.N., Ratnikov, B.I., Rozanov, D.V., Godzik, A., Deryugina, E.I., Strongin, A.Y., Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin (2001) Biochem J, 356, pp. 705-718
Mestdagt, M., Polette, M., Buttice, G., Noel, A., Ueda, A., Foidart, J.M., Gilles, C., Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells (2006) Int J Cancer, 118, pp. 35-42
Polette, M., Gilles, C., de Bentzmann, S., Gruenert, D., Tournier, J.M., Birembaut, P., Association of fibroblastoid features with the invasive phenotype in human bronchial cancer cell lines (1998) Clin Exp Metastasis, 16, pp. 105-112
Polette, M., Nawrocki-Raby, B., Gilles, C., Clavel, C., Birembaut, P., Tumour invasion and matrix metalloproteinases (2004) Crit Rev Oncol Hematol, 49, pp. 179-186
Polette, M., Gilles, C., Nawrocki-Raby, B., Lohi, J., Hunziker, W., Foidart, J.M., Birembaut, P., Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells (2005) Cancer Res, 65, pp. 7691-7698
Pulyaeva, H., Bueno, J., Polette, M., Birembaut, P., Sato, H., Seiki, M., Thompson, E.W., MT1-MMP correlates with MMP-2 activation potential seen after epithelial to mesenchymal transition in human breast carcinoma cells (1997) Clin Exp Metastasis, 15, pp. 111-120
Reichert, M., Muller, T., Hunziker, W., The PDZ domains of zonula occludens-1 induce an epithelial to mesenchymal transition of Madin-Darby canine kidney I cells. Evidence for a role of beta-catenin/Tcf/Lef signaling (2000) J Biol Chem, 275, pp. 9492-9500
Singh, S., Sadacharan, S., Su, S., Belldegrun, A., Persad, S., Singh, G., Overexpression of vimentin: Role in the invasive phenotype in an androgen-independent model of prostate cancer (2003) Cancer Res, 63, pp. 2306-2311
Sommers, C.L., Walker-Jones, D., Heckford, S.E., Worland, P., Valverius, E., Clark, R., McCormick, F., Gelmann, E.P., Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells (1989) Cancer Res, 49, pp. 4258-4263
Sommers, C.L., Heckford, S.E., Skerker, J.M., Worland, P., Torri, J.A., Thompson, E.W., Byers, S.W., Gelmann, E.P., Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines (1992) Cancer Res, 52, pp. 5190-5197
Sommers, C.L., Byers, S.W., Thompson, E.W., Torri, J.A., Gelmann, E.P., Differentiation state and invasiveness of human breast cancer cell lines (1994) Breast Cancer Res Treat, 31, pp. 325-335
Sommers, C.L., Skerker, J.M., Chrysogelos, S.A., Bosseler, M., Gelmann, E.P., Regulation of vimentin gene transcription in human breast cancer cell lines (1994) Cell Growth Differ, 5, pp. 839-846
Steinert, P.M., Roop, D.R., Molecular and cellular biology of intermediate filaments (1988) Annu Rev Biochem, 57, pp. 593-625
Sternlicht, M.D., Lochter, A., Sympson, C.J., Huey, B., Rougier, J.P., Gray, J.W., Pinkel, D., Werb, Z., The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis (1999) Cell, 98, pp. 137-146
Takahashi, M., Tsunoda, T., Seiki, M., Nakamura, Y., Furukawa, Y., Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers (2002) Oncogene, 21, pp. 5861-5867
Thiery, J.P., Epithelial-mesenchymal transitions in development and pathologies (2003) Curr Opin Cell Biol, 15, pp. 740-746
Thompson, E.W., Paik, S., Brunner, N., Sommers, C.L., Zugmaier, G., Clarke, R., Shima, T.B., Lippman, M.E., Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines (1992) J Cell Physiol, 150, pp. 534-544
Wheelock, M.J., Johnson, K.R., Cadherins as modulators of cellular phenotype (2003) Annu Rev Cell Dev Biol, 19, pp. 207-235
