Risk factors for Zaire ebolavirus--specific IgG in rural Gabonese populations.

[en] BACKGROUND: In Gabon, several Ebolavirus outbreaks have occurred exclusively in the northeastern region. We conducted a large serosurvey to identify areas and populations at risk and potential demographic, clinical, and behavioral risk factors. METHODS: Blood samples and clinical and sociodemographic data were collected from 4349 adults and 362 children in a random sample of 220 villages in the 9 provinces of Gabon. An enzyme-linked immunosorbent assay was used to detect Zaire ebolavirus (ZEBOV)-specific IgG, and thin blood smears were used to detect parasites. Logistic regression was implemented using Stata software (Stata), and a probability level of <.05 was considered to be statistically significant. RESULTS: The prevalence of ZEBOV-specific IgG was 15.3% overall, increasing to 32.4% (P< .001) in forest areas. No sociodemographic risk factors were found, but the antibody prevalence increased linearly up to 20 years of age. Chronic arthralgia and amicrofilaremia were the only factors associated with ZEBOV seropositivity. CONCLUSIONS: These findings confirm the endemicity of ZEBOV in Gabon and its link to the ecosystem. Human antibody positivity would appear to be to the result of exposure to contaminated fruits.

Disciplines :

Immunology & infectious disease

Author, co-author :

Nkoghe Mba, Dieudonne ; Université de Liège - ULiège > Doct. sc. médicales (Bologne)

Padilla, Cindy

Becquart, Pierre

Wauquier, Nadia

Moussavou, Ghislain

Akué, Jean Paul

Ollomo, Benjamin

Pourrut, Xavier

Souris, Marc

Kazanji, Mirdad

Gonzalez, Jean-Paul

Leroy, Eric

Language :

English

Title :

Risk factors for Zaire ebolavirus--specific IgG in rural Gabonese populations.

Publication date :

19 December 2011

Journal title :

Journal of Infectious Diseases

ISSN :

0022-1899

eISSN :

1537-6613

Publisher :

University of Chicago Press, Chicago, United States - Illinois

Volume :

204 Suppl 3

Pages :

S768-75

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 June 2013

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