Apoptosis characterizes immunological failure of HIV infected patients

[en] This paper studies the influence of apoptosis in the dynamics of the HIV infection. A new modeling of the healthy CD4+ T-cells activation-induced apoptosis is used. The parameters of this model are identified by using clinical data generated by monitoring patients starting Highly Active Anti-Retroviral Therapy (HAART). The sampling of blood tests is performed to satisfy the constraints of dynamical system parameter identification. The apoptosis parameter, which is inferred from clinical data, is then shown to play a key role in the early diagnosis of immunological failure.

Disciplines :

Immunology & infectious disease
Computer science

Author, co-author :

Mhawej, Marie-José

Brunet-Francois, Cécile

Fonteneau, Raphaël ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation

Ernst, Damien ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation

Ferré, Virginie

Stan, Guy-Bart

Raffi, François

Moog, Claude H.

Language :

English

Title :

Apoptosis characterizes immunological failure of HIV infected patients

Publication date :

July 2009

Journal title :

Control Engineering Practice

ISSN :

0967-0661

Publisher :

Pergamon Press - An Imprint of Elsevier Science

Volume :

Issue :

Pages :

798-804

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.elsevier.com/wps/find/journaldescription.cws_home/123/description#description
http://www.montefiore.ulg.ac.be/~ernst/

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 19 June 2009

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