[en] This paper studies the influence of apoptosis in the dynamics of the HIV infection. A new modeling of the healthy CD4+ T-cells activation-induced apoptosis is used. The parameters of this model are identified by using clinical data generated by monitoring patients starting Highly Active Anti-Retroviral Therapy (HAART). The sampling of blood tests is performed to satisfy the constraints of dynamical system parameter identification. The apoptosis parameter, which is inferred from clinical data, is then shown to play a key role in the early diagnosis of immunological failure.
Disciplines :
Immunology & infectious disease Computer science
Author, co-author :
Mhawej, Marie-José
Brunet-Francois, Cécile
Fonteneau, Raphaël ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Ernst, Damien ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Ferré, Virginie
Stan, Guy-Bart
Raffi, François
Moog, Claude H.
Language :
English
Title :
Apoptosis characterizes immunological failure of HIV infected patients
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