Reference : Quality controls of no-carrier-added aromatic amino acids such as FDOPA and FTYR prod...
Scientific congresses and symposiums : Poster
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/149346
Quality controls of no-carrier-added aromatic amino acids such as FDOPA and FTYR produced at curie level
English
Libert, Lionel mailto [Université de Liège - ULiège > > > Doct. sc. (chimie - Bologne)]
Lemaire, Christian mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Giacomelli, Fabrice mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Léonard, Marc mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Plenevaux, Alain mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Franci, Xavier mailto []
Luxen, André mailto [Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse >]
May-2013
900 X 1200 mm (A0)
Yes
International
The 20th International Symposium on Radiopharmaceutical Science
du 12 mai 2013 au 17 mai 2013
The Society of Radiopharmaceutical Sciences
Jeju
Korea
[en] 18F-FDOPA ; 18F-Fluoride ; Quality control ; Curie level
[en] Aromatic fluoro amino acids such as 2-[18F]fluoro-L-tyrosine (FTYR) and 6-[18F]fluoro-L-DOPA (FDOPA) are useful radiopharmaceuticals for oncologic studies and evaluation of the presynaptic dopaminergic function using positron emission tomography. Recently, a no-carrier-added (nca) enantioselective synthesis of these compounds, based on an multistep PTC approach was automated in a FASTlabTM module from GE . From 185 GBq of [18F]fluoride and after 1 hour of synthesis, more than 37 GBq of FTYR or FDOPA are available . This automated production yields enough doses for many PET studies. A monograph for FDOPA prepared by electrophilic substitution exists , but it is not adapted to the nca nucleophilic synthesis of FDOPA and FTYR, as in this case specific activity, by products and possible impurities are different. A complete quality control (QC) has then be developed in accordance with the guidelines of the European Pharmacopeia (Eur. Ph.).
Centre de Recherches du Cyclotron - CRC
Université de Liège
http://hdl.handle.net/2268/149346

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