The African coelacanth genome provides insights into tetrapod evolution.

Animals; Animals, Genetically Modified; Biological Evolution; Chick Embryo; Conserved Sequence/genetics; Enhancer Elements, Genetic/genetics; Evolution, Molecular; Extremities/anatomy & histology/growth & development; Fishes/anatomy & histology/classification/genetics/physiology; Genes, Homeobox/genetics; Genome/genetics; Genomics; Immunoglobulin M/genetics; Mice; Molecular Sequence Annotation; Molecular Sequence Data; Phylogeny; Sequence Alignment; Sequence Analysis, DNA; Vertebrates/anatomy & histology/genetics/physiology

Abstract :

[en] The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.

Disciplines :

Genetics & genetic processes
Biochemistry, biophysics & molecular biology
Zoology

Author, co-author :

Amemiya, Chris T.

Alfoldi, Jessica

Lee, Alison P.

Fan, Shaohua

Philippe, Herve

Maccallum, Iain

Braasch, Ingo

Manousaki, Tereza

Schneider, Igor

Rohner, Nicolas

More authors (81 more)

Language :

English

Title :

The African coelacanth genome provides insights into tetrapod evolution.

Publication date :

2013

Journal title :

Nature

ISSN :

0028-0836

eISSN :

1476-4687

Publisher :

Nature Publishing Group, London, United Kingdom

Volume :

496

Issue :

7445

Pages :

311-6

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.nature.com/nature/journal/v496/n7445/full/nature12027.html

Available on ORBi :

since 16 May 2013

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Scopus citations^®

565

Scopus citations^®
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456

OpenCitations

542

OpenAlex citations

652

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