Reference : Discriminative stimulus effects of ethanol: Lack of interaction with taurine
Scientific journals : Article
Human health sciences : Psychiatry
Human health sciences : Pharmacy, pharmacology & toxicology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/1483
Discriminative stimulus effects of ethanol: Lack of interaction with taurine
English
Quertemont, Etienne mailto [Université de Liège - ULiège > Département des sciences cognitives > Psychologie quantitative >]
Grant, Kathleen A. [Wake Forest University > Department of Physiology and Pharmacology > Center for the Neurobehavioral Study of Alcohol > >]
2004
Behavioural Pharmacology
Lippincott Williams & Wilkins
15
7
495-501
Yes (verified by ORBi)
International
0955-8810
London
United Kingdom
[en] ethanol ; taurine ; drug discrimination ; rat
[en] Recent microdialysis studies showed that ethanol administration increases the release of taurine in various rat brain regions, and it was suggested that this increase in extracellular concentrations of taurine might mediate some of the neurochemical effects of ethanol. Previous drug discrimination studies showed that positive modulators of the GABA(A) receptor consistently substituted for ethanol discriminative stimulus effects. Since taurine is also believed to modulate GABA(A) receptor activity, this study addressed the hypothesis that taurine mediates the discriminative stimulus effects of ethanol due to GABA(A) activation. Male Long-Evans rats were trained to discriminate water from either 1 or 2 g/kg ethanol. In a first experiment, various taurine doses (0-500 mg/kg) were tested to investigate whether taurine substitutes for ethanol. In a second experiment, rats were pretreated with either 500 mg/kg taurine or an equivalent volume of saline before testing for ethanol discrimination with various ethanol doses (0-2.0 g/kg). The results showed that taurine does not substitute for ethanol at any tested doses. In addition, taurine pretreatments failed to modify the dose-response curve for ethanol discrimination. These results demonstrate that taurine is not directly involved in mediating the discriminative stimulus effects of ethanol. It is therefore very unlikely that the brain release of taurine observed after ethanol administration is implicated in the major pharmacological effects of ethanol, i.e. positive modulation of GABA(A) receptor, that mediate its discriminative stimulus effects.
Centre de Neurosciences Cognitives et comportementales
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; National Institute on Alcohol Abuse and Alcoholism
Researchers ; Professionals
http://hdl.handle.net/2268/1483
10.1097/00008877-200411000-00005

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