Specificity of Inhibitory Deficits in Normal Aging and Alzheimer's Disease

[en] Deficits of suppression abilities are frequently observed in normal aging and Alzheimer's disease. However, few studies have explored these deficits in the two populations simultaneously using a large battery of tasks. The aim of the present study was to explore if the pattern of performance presented by elderly subjects and AD patients is in agreement with theoretical frameworks [Wilson, S.P., Harnishfeger, K.K., 1998. The development of efficient inhibition: Evidence from directed forgetting tasks. Dev. Rev. 18, 86-123; see also Nigg J.T., 2000. On inhibition/disinhibition in developmental psychopathology: views from cognitive and personality psychology and a working inhibition taxonomy. Psychol. Bull. 126, 220-246], distinguishing between the concepts of inhibition (a voluntary suppression of irrelevant information) and interference (an automatic suppression process occurring prior to conscious awareness). The results obtained demonstrated that (1) there is an alteration of the inhibitory process in normal elderly subjects; (2) inhibitory and interference resolution processes are quantitately less efficient in AD, since these patients present a correct performance only for information which leaves weak traces in memory.

Research center :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Centre de Neurosciences Cognitives et Comportementales - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie

Schmidt, Christina ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie

Scherrer, Christine

Adam, Stéphane ; Université de Liège - ULiège > Département des sciences cognitives > Département des sciences cognitives

Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Language :

English

Title :

Specificity of Inhibitory Deficits in Normal Aging and Alzheimer's Disease

Publication date :

26 April 2009

Journal title :

Neurobiology of Aging

ISSN :

0197-4580

eISSN :

1558-1497

Publisher :

Elsevier, New York, United States - New York

Volume :

Pages :

875-889

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]

Commentary :

http://www.neurobiologyofaging.org/

Available on ORBi :

since 16 June 2009

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