A multilayer braided scaffold for Anterior Cruciate Ligament : mechanical modeling at the fiber scale

[en] An adapted scaffold for Anterior Cruciate Ligament (ACL) tissue engineering must match biological, morphological and biomechanical requirements. Computer-aided tissue engineering consists of finding the most appropriate scaffold regarding a specific application by using numerical tools. In the present study, the biomechanical behavior of a new multilayer braided scaffold adapted to computer-aided tissue engineering is computed by using a dedicated Finite Element (FE) code. Among different copoly(lactic acid-co-(ε-caprolactone)) (PLCL) fibers tested in the present study, PLCL fibers with a lactic acid/ε-caprolactone ratio of 85/15 were selected as a constitutive material for the scaffold considering its strength and deformability. The mechanical behavior of these fibers was utilized as material input in a Finite Element (FE) code which considers contact/friction interactions between fibers within a large deformation framework. An initial geometry issued from the braiding process was then computed and was found to be representative of the actual scaffold geometry. Comparisons between simulated tensile tests and experimental data show that the method enables to predict the tensile response of the multilayer braided scaffold as a function of different process parameters. As a result, the present approach constitutes a valuable tool in order to determine the configuration which best fits the biomechanical requirements needed to restore the knee function during the rehabilitation period. The developed approach also allows the mechanical stimuli due to external loading to be quantified, and will be used to perform further mechanobiological analyses of the scaffold under dynamic culture.

Disciplines :

Engineering, computing & technology: Multidisciplinary, general & others

Author, co-author :

Laurent, Cédric ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > LTAS-Mécanique numérique non linéaire

DURVILLE, D

MAINARD, D

GANGHOFFER, J-F

RAHOUADJ, R

Language :

English

Title :

A multilayer braided scaffold for Anterior Cruciate Ligament : mechanical modeling at the fiber scale

Alternative titles :

[en] Une matrice tressée multicouche pour le ligament croisé antérieur: modélisation mécanique à l'échelle de la fibre

Publication date :

2012

Journal title :

Journal of Mechanical behaviour of biomedical materials

Volume :

Pages :

184-196

Peer reviewed :

Peer reviewed

Available on ORBi :

since 03 April 2013

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Bibliography

Altman G.H., Horan R.L., Lu H.H., Moreau J., Martin I., Richmond J.C., Kaplan D.L. Silk matrix for tissue engineered anterior cruciate ligament. Biomaterials 2002, 23:4131-4141.
Beynnon B.D., Fleming B.C. Anterior cruciate ligament strain in-vivo-a review of previous work. Journal of Biomechanics 1998, 31:519-525.
Butler D.L., Goldstein S.A., Guldberg R.E., Guo X.E., Kamm R., Laurencin C.T., McIntire L.V., Mow V.C., Nerem R.M., Sah R.L., Soslowsky L.J., Spilker R., Tranquillo R.T. The impact of biomechanics in tissue engineering and regenerative medecine. Tissue Engineering Part B 2009, 15(4):477-484.
Butler D.L., Hunter S.A., Chokalingam K., Cordray M.J., Shearn J., Juncosa-Melvin N., Nirmalanandhan S., Jain A. Using functional tissue engineering and bioreactors to mechanically stimulate tissue-engineered constructs. Tissue Engineering Part A 2009, 15(4):741-749.
Butler D.L., Stouffer D.C. Tension-torsion characteristics of the canine anterior cruciate ligament-part II: experimental observations. Journal of Biomechanical Engineering 1983, 105:160-165.
Chan K.S., Liang W., Francis W.L., Nicolella D.P. A multiscale modeling approach to scaffold design and property prediction. Journal of the Mechanical Behavior of Biomedical Materials 2010, 3:584-593.
Chen G., Ushida T., Tateishi T. Development of biodegradable porous scaffolds for tissue engineering. Materials Science and Engineering C 2001, 17:63-69.
Cheng C.-M., Steward R.L., Leduc P.R. Probing cell structure by controlling the mechanical environment with cell-substrate interactions. Journal of Biomechanics 2009, 42:187-192.
Cooper J.A., Lu H.H., Ko F.K., Freeman J.W., Laurencin C.T. Fiber-based tissue-engineered scaffold for ligament replacement - design considerations and in vitro evaluation. Biomaterials 2005, 26:1523-1532.
Dargel J., Gotter M., Mader K., Pennig D., Koebke J., Schmidt-Wiethoff R. Biomechanics of the anterior cruciate ligament and implications for surgical reconstruction. Strategies in Trauma and Limb Reconstruction 2007, 2:1-12.
Durville, D., 2012. Contact-friction modeling within elastic beam assemblies: an application to knot tightening. Computational Mechanics, in press. http://dx.doi.org/10.1007/s00466-012-0683-0.
Fan H., Liu H., Toh S.L., Goh J.C.H. Anterior cruciate ligament regeneration using mesenchymal stem cells and silk scaffold in large animal model. Biomaterials 2009, 30:4967-4977.
Fang Z., Starly B., Sun W. Computer-aided characterization for effective mechanical properties of porous tissue scaffolds. Computer-Aided Design 2005, 37:65-72.
Frank C.B., Jackson D.W. Curreag pbaprcgf erivrj-gur fpvrapr bs erpbafgehpgvba bs gur nagrevbe pehpvngr yvtnzrag. The Journal of Bone and Joint Surgery 1997, 79(10):1556-1576.
Gao B., Zheng N.N. Alterations in three-dimensional joint kinematics of anterior cruciate ligament-deficient and -reconstructed knees during walking. Clinical Biomechanics 2010, 25:22-229.
Gentleman E., Livesay G.A., Dee K.C., Nauman E.A. Development of ligament-like structural organization and properties in cell-seeded collagen scaffolds in vitro. Annals of Biomedical Engineering 2006, 34:726-736.
Hiljanen-Vainio M.P., Orava P.A., Seppala J.V. Properties of e-caprolactone-DL-lactide (e-CL-DL-LA) copolymers with a minor e-CL content. Journal of Biomedical Materials Research 1997, 34:39-46.
Ingber D.E. Cellular mechanotransduction- putting all the pieces together again. The FASEB Journal 2006, 20:811-827.
Jaecques S.V.N., Van Oosterwyck H., Muraru L., Van Cleynenbreugel T., De Smet E., Wevers M., Naert I., Sloten J.V. Individualised, micro CT-based finite element modelling as a tool for biomechanical analysis related to tissue engineering of bone. Biomaterials 2004, 25:1683-1696.
Jeong S.I., Kim B.-S., Kang S.W., Kwon J.H., Lee Y.M., Kim S.H. In vivo biocompatibilty and degradation behavior of elastic poly-L-lactide-co-e-caprolactone scaffolds. Biomaterials 2004, 25:5939-5946.
Jeong S.I., Lee Y.M. Tissue engineering using a cyclic strain bioreactor and gelatin-plcl scaffolds. Macromolecular Research 2008, 16:567-569.
Jones A.C., Arns C.H., Hutmacher D.W., Milthorpe B.K., Sheppard A.P., Knackstedt M.A. The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth. Biomaterials 2009, 30:1440-1451.
Jones R.S., Nawana N.S., Pearcy M.J., Learmonth D.J.A., Bickerstaff D.R., Costi J.J., Paterson R.S. Mechanical properties of the human anterior cruciate ligament. Clinical Biomechanics 1995, 10:339-344.
Karmani S., Ember T. The anterior cruciate ligament-I. Current Orthopaedics 2003, 17:369-377.
Karmani S., Ember T. The anterior cruciate ligament-II. Current Orthopaedics 2003, 18:49-57.
Kimura Y., Hokugo A., Takamoto T., Tabata Y., Kurosawa H. Regeneration of anterior cruciate ligament by biodegradable scaffold combined with local controlled release of basic fibroblast growth factor and collagen wrapping. Tissue Engineering Part C 2008, 14(1):47-57.
Lacroix D., Château A., Ginebra M.-P., Planell J.A. Micro-finite element models of bone tissue-engineering scaffolds. Biomaterials 2006, 27:5326-5334.
Laurent C.P., Ganghoffer J.-F., Babin J., Six J.-L., Wang X., Rahouadj R. Morphological characterization of a novel scaffold for anterior cruciate ligament tissue engineering. Journal of Biomechanical Engineering 2011, 133. 065001-1-065001-9.
Li G., Papannagari R., DeFrate L.E., Yoo J.D., Park S.E., Gill T.J. Comparison of the ACL and ACL graft forces before and after ACL reconstruction. Acta Orthopaedica 2006, 77:267-274.
Meek M.F., Jansen K. Two years after in vivo implantation of poly(DL-lactide-e-caprolactone) nerve guides: has the material finally resorbed?. Journal of Biomedical Materials Research-Part A 2009, 89:734-738.
Melchels F.P.W., Barradas A.M.C., van Blitterswijk C.A., de Boer J., Feijen J., Grijpma D.W. Effects of the architecture of tissue engineering scaffolds on cell seeding and culturing. Acta Biomaterialia 2010, 6:4208-4217.
Moraiti C.O., Stergiou N., Vasiliadis H.S., Motsis E., Georgoulis A. Anterior cruciate ligament reconstruction results in alterations in gait variability. Gait & Posture 2010, 32:169-175.
Oh S.H., Park I.K., Kim J.M., Lee J.H. In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method. Biomaterials 2007, 28:1664-1671.
Omeroglu S. The effect of braiding parameters on the mechanical properties of braided ropes. Fibres and Textiles in Eastern Europe 2006, 14:53-57.
Pioletti D.P., Rakotomanana L.R. On the independence of time and strain effects in the stress relaxation of ligaments and tendons. Journal of Biomechanics 2000, 33:1729-1732.
Plaweski S., Grimaldi M., Courvoisier A., Wimsey S. Intraoperative comparisons of knee kinematics of double-bundle versus single-bundle anterior cruciate ligament reconstruction. Knee Surgery, Sports Traumatology, Arthroscopy 2011, 19(8):1277-1298.
Saito E., Kang H., Taboas J.M., Diggs A., Flanagan C.L., Hollister S.J. Experimental and computational characterization of designed and fabricated 50:50 PLGA porous scaffolds for human trabecular bone applications. Journal of Materials Science: Materials in Medicine 2010, 21:2371-2383.
Sandino C., Lacroix D. A dynamical study of the mechanical stimuli and tissue differentiation within a CaP scaffold based on micro-CT finite element models. Biomechanics and Modeling in Mechanobiology 2011, 10(4):565-576.
Sandino C., Planell J.A., Lacroix D. A finite element study of mechanical stimuli in scaffolds for bone tissue engineering. Journal of Biomechanics 2008, 41:1005-1014.
Screen H.R.C. Investigating load relaxation mechanics in tendon. Journal of the Mechanical Behavior of Biomedical Materials 2008, 1:51-58.
Shen W., Jordan S., Fu F. Review article- Anatomic double bundle anterior cruciate ligament reconstruction. The Journal of Orthopaedic Surgery 2007, 15:216-221.
Smith P.A., Lubowitz J.H. No-tunnel double-bundle anterior cruciate ligament retroconstruction- the all-inside x 2 technique. Operative Techniques in Sports Medicine 2009, 17(1):62-68.
Stops A.J.F., Harrison N.M., Haugh M.G., O'Brien F.J., McHugh P.E. Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis. Journal of the Mechanical Behavior of Biomedical Materials 2010, 3:292-302.
Toutoungi D.E., Lu T.W., Leardini A., Catani F., O'Connor J.J. Cruciate ligament forces in the human knee during rehabilitation exercises. Clinical Biomechanics 2000, 15:176-187.
Unwin A. What's new in anterior cruciate ligament surgery. Orthopaedics and Trauma 2010, 24(2):100-106.
Vilay V., Mariatti M., Ahmad Z., Pasomsouk K., Todo M. Characterization of the mechanical and thermal properties and morphological behavior of biodegradable poly-l-lactide - poly-e-caprolactone and poly-l-lactide-poly-butylene succinate-co-l-lactate polymeric blends. Journal of Applied Polymer Science 2009, 114:1784-1792.
Vunjak-Novakovic G., Altman G., Horan K., Kaplan D.L. Tissue engineering of ligaments. Annual Review of Biomedical Engineering 2004, 6:131-156.
Yasuda K., Tanabe Y., Kondo E., Kitamura N., Tohyama H. Anatomic double-bundle anterior cruciate ligament reconstruction. Arthroscopy: The Journal of Arthroscopy and Related Surgery 2010, 26:S21-S34.