[en] We develop a wavelet-based multiscale pattern recognition methodology to disentangle the replication-
from the transcription-associated compositional strand asymmetries observed in the human genome.
Comparing replication skew profiles to recent high-resolution replication timing data reveals that most of
the putative replication origins that border the so-identified replication domains are replicated earlier than
their surroundings whereas the central regions replicate late in the S phase. We discuss the implications of
this first experimental confirmation of these replication origin predictions that are likely to be early
replicating and active in most tissues.
Disciplines :
Mathematics
Author, co-author :
Audit, Benjamin
Nicolay, Samuel ; Université de Liège - ULiège > Département de mathématique > Analyse - Analyse fonctionnelle - Ondelettes
Huvet, Maxime
Touchon, Marie
d'Aubenton-Carafa, Yves
Thermes, Claude
Arneodo, Alain L.
Language :
English
Title :
DNA replication timing data corroborate in silico human replication origin predictions
Publication date :
2007
Journal title :
Physical Review Letters
ISSN :
0031-9007
eISSN :
1079-7114
Publisher :
American Physical Society, Ridge, United States - New York
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Bibliography
F. Jacob, S. Brenner, and F. Cuzin, Cold Spring Harbor Symposia on Quantitative Biology CSHSAZ 0091-7451 28, 329 (1963).
R. Berezney, D.D. Dubey, and J.A. Huberman, Chromosoma 108, 471 (2000); CHROAU 1432-0886 10.1007/s004120050399
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