Adachi, S., Yamada, S., Takatsu, Y., Matsui, H., Kinoshita, M., Takase, K., et al. (2007). Involvement of anteroventricular periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats. J. Reprod. Dev. 53, 367-378.
Ancel, C., Bentsen, A. H., Sébert, M. E., Tena-Sempere, M., Mikkelsen, J. D., and Simonneaux, V. (2012). Stimulatory effect of RFRP-3 on the gonadotrophic axis in the male Syrian hamster: the exception proves the rule. Endocrinology 153, 1352-1363.
Backholer, K., Smith, J. T., Rao, A., Pereira, A., Iqbal, J., Ogawa, S., et al. (2010). Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. Endocrinology 151, 2233-2243.
Bakker, J., Pierman, S., and González-Martínez, D. (2010). Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones. Horm. Behav. 57, 390-395.
Bateman, H. L., and Patisaul, H. B. (2008). Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus. Neurotoxicology 29, 988-997.
Bellingham, M., Fowler, P. A., Amezaga, M. R., Rhind, S. M., Cotinot, C., Mandon-Pepin, B., et al. (2009). Exposure to a complex cocktail of environmental endocrine-disrupting compounds disturbs the kisspeptin/GPR54 system in ovine hypothalamus and pituitary gland. Environ. Health Perspect. 117, 1556-1562.
Caldani, M., Batailler, M., Thiéry, J. C., and Dubois, M. P. (1988). LHRH-immunoreactive structures in the sheep brain. Histochemistry 89, 129-139.
Cao, J., Mickens, J. A., McCaffrey, K. A., Leyrer, S. M., and Patisaul, H. B. (2012). Neonatal bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus. Neurotoxicology 33, 23-36.
Cao, J., and Patisaul, H. B. (2011). Sexually dimorphic expression of hypothalamic estrogen receptors ??. and ??. and Kiss1 in neonatal male and female rats. J. Comp. Neurol. 519, 2954-2977.
Caron, E., Ciofi, P., Prevot, V., and Bouret, S. G. (2012). Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function. J. Neurosci. 32, 11486-11494.
Castellano, J. M., Bentsen, A. H., Sánchez-Garrido, M. A., Ruiz-Pino, F., Romero, M., Garcia-Galiano, D., et al. (2011). Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system. Endocrinology 152, 3396-3408.
Castellano, J. M., Navarro, V. M., Fernández-Fernández, R., Castaño, J. P., Malagón, M. M., Aguilar, E., et al. (2006). Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat. Mol. Cell. Endocrinol. 257-258, 75-83.
Castellano, J. M., Navarro, V. M., Fernández-Fernández, R., Nogueiras, R., Tovar, S., Roa, J., et al. (2005). Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology 146, 3917-3925.
Cheng, G., Coolen, L. M., Padmanabhan, V., Goodman, R. L., and Lehman, M. N. (2010). The kisspeptin/neurokinin B/dynorphin (KNDy) cell population of the arcuate nucleus: sex differences and effects of prenatal testosterone in sheep. Endocrinology 151, 301-311.
Clarke, I. J. (2011). Control of GnRH secretion: one step back. Front. Neuroendocrinol. 32, 367-375.
Clarkson, J., Boon, W. C., Simpson, E. R., and Herbison, A. E. (2009). Postnatal development of an oestradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinology 150, 3214-3220.
Clarkson, J., d'Anglemont de Tassigny, X., Moreno, A. S., Colledge, W. H., and Herbison, A. E. (2008). Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. J. Neurosci. 28, 8691-8867.
Clarkson, J., and Herbison, A. E. (2006). Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin -releasing hormone neurons. Endocrinology 147, 5817-5825.
Constantin, S., Caraty, A., Wray, S., and Duittoz, A. H. (2009a). Development of gonadotropin-releasing hormone-1 secretion in mouse nasal explants. Endocrinology 150, 3221-3227.
Constantin, S., Caligioni, C. S., Stojilkovic, S., and Wray, S. (2009b). Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropinreleasing hormone-1 neurons. Endocrinology 150, 1400-1412.
Cravo, R. M., Margatho, L. O., Osborne-Lawrence, S., Donato, J. Jr., Atkin, S., Bookout, A. L., et al. (2011). Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience 173, 37-56.
d'Anglemont de Tassigny, X., Fagg, L. A., Dixon, J. P., Day, K., Leitch, H. G., Hendrick, A. G., et al. (2007). Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc. Natl. Acad. Sci. U.S.A. 104, 10714-10719.
de Roux, N., Genin, E., Carel, J. C., Matsuda, F., Chaussain, J. L., and Milgrom, E. (2003). Hypogonadotropic hypogonadism due to loss of function of the KiSS1- derived peptide receptor GPR54. Proc. Natl. Acad. Sci. U.S.A. 100, 10972-10976.
Desroziers, E., Droguerre, M., Bentsen, A. H., Robert, V., Mikkelsen, J. D., Caraty, A., et al. (2012a). Embryonic development of kisspeptin neurones in rat. J. Neuroendocrinol. 24, 1284-1295.
Desroziers, E., Mikkelsen, J. D., Duittoz, A., and Franceschini, I. (2012b). Kisspeptin-immunoreactive changes in a sex- and hypothalamic-region-specific manner across rat postnatal development. J. Neuroendocrinol. 24, 1154-1165.
Desroziers, E., Mikkelsen, J., Simonneaux, V., Keller, M., Tillet, Y., Caraty, A., et al. (2010). Mapping of kisspeptin fibres in the brain of the pro-oestrous rat. J. Neuroendocrinol. 22, 1101-1112.
Dickerson, S. M., Cunningham, S. L., Patisaul, H. B., Woller, M. J., and Gore, A. C. (2011a). Endocrine disruption of brain sexual differentiation by developmental PCB exposure. Endocrinology 152, 581-594.
Dickerson, S. M., Cunningham, S. L., and Gore, A. C. (2011b). Prenatal PCBs disrupt early neuroendocrine development of the rat hypothalamus. Toxicol. Appl. Pharmacol. 252, 36-46.
Döhler, K. D., and Wuttke, W. (1975). Changes with age in levels of serum gonadotropins, prolactin and gonadal steroids in prepubertal male and female rats. Endocrinology 97, 898-907.
Ducret, E., Gaidamaka, G., and Herbison, A. E. (2010). Electrical and morphological characteristics of anteroventral periventricular nucleus kisspeptin and other neurons in the female mouse. Endocrinology 151, 2223-2232.
Dungan, H. M., Gottsch, M. L., Zeng, H., Gragerov, A., Bergmann, J. E., Vassilatis, D. K., et al. (2007). The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone. J. Neurosci. 27, 12088-12095.
Eghlidi, D. H., Haley, G. E., Noriega, N. C., Kohama, S. G., and Urbanski, H. F. (2010). Influence of age and 17beta-oestradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques. Endocrinology 151, 3783-3794.
Elias, C. F., and Purohit, D. (2013). Leptin signaling and circuits in puberty and fertility. Cell Mol. Life Sci. 70, 841-862.
Fiorini, Z., and Jasoni, C. L. (2010). A novel developmental role for kisspeptin in the growth of gonadotrophin-releasing hormone neurites to the median eminence in the mouse. J. Neuroendocrinol. 22, 1113-1125.
Forbes, S., Li, X. F., Kinsey-Jones, J., and O'Byrne, K. (2009). Effects of ghrelin on kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat. Neurosci. Lett. 460, 143-147.
Franceschini, I., Lomet, D., Cateau, M., Delsol, G., Tillet, Y., and Caraty, A. (2006). Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co -express estrogen receptor alpha. Neurosci. Lett. 401, 225-230.
Funes, S., Hedrick, J. A., Vassileva, G., Markowitz, L., Abbondanzo, S., Golovko, A., et al. (2003). The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. Biochem. Biophys. Res. Commun. 312, 1357-1363.
García-Galiano, D., Pineda, R., Roa, J., Ruiz-Pino, F., Sánchez-Garrido, M. A., Castellano, J. M., et al. (2012a). Differential modulation of gonadotropin responses to kisspeptin by aminoacidergic, peptidergic, and nitric oxide neurotransmission. Am. J. Physiol. Endocrinol. Metab. 303, E1252-E1263.
García-Galiano, D., van Ingen Schenau, D., Leon, S., Krajnc-Franken, M. A., Manfredi-Lozano, M., Romero-Ruiz, A., et al. (2012b). Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology 153, 316-328.
Gill, J. C., Navarro, V. M., Kwong, C., Noel, S. D., Martin, C., Xu, S., et al. (2012). Increased neurokinin B (tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than kiss1. Endocrinology 153, 4883-4893.
Gill, J. C., Wang, O., Kakar, S., Martinelli, E., Carroll, R. S., and Kaiser, U. B. (2010). Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. PLoS ONE 5, e11911. doi:10.1371/journal.pone.0011911
González-Martínez, D., De Mees, C., Douhard, Q., Szpirer, C., and Bakker, J. (2008). Absence of gonadotropin-releasing hormone 1 and Kiss1 activation in alphafetoprotein knockout mice, prenatal estrogens defeminize the potential to show preovulatory luteinizing hormone surges. Endocrinology 149, 2333-2340.
Goodman, R. L., Maltby, M. J., Millar, R. P., Hileman, S. M., Nestor, C. C., Whited, B., et al. (2012). Evidence that dopamine acts via kisspeptin to hold GnRH pulse frequency in check in anestrous ewes. Endocrinology 153, 5918-5927.
Gore, A. C., Walker, D. M., Zama, A. M., Armenti, A. E., and Uzumcu, M. (2011). Early life exposure to endocrine-disrupting chemicals causes lifelong molecular reprogramming of the hypothalamus and premature reproductive aging. Mol. Endocrinol. 25, 2157-2168.
Gore, A. C., Windsor-Engnell, B. M., and Terasawa, E. (2004). Menopausal increases in pulsatile gonadotropin-releasing hormone release in a nonhuman primate (Macaca mulatta). Endocrinology 145, 4653-4659.
Grachev, P., Li, X. F., Lin, Y. S., Hu, M. H., Elsamani, L., Paterson, S. J., et al. (2012). GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. PLoS ONE 7, e44344. doi:10.1371/journal.pone.0044344
Guerriero, K. A., Keen, K. L., Millar, R. P., and Terasawa, E. (2012a). Developmental changes in GnRH release in response to kisspeptin agonist and antagonist in female rhesus monkeys (Macaca mulatta), implication for the mechanism of puberty. Endocrinology 153, 825-836.
Guerriero, K. A., Keen, K. L., and Terasawa, E. (2012b). Developmental increase in kisspeptin-54 release in vivo is independent of the pubertal increase in oestradiol in female rhesus monkeys (Macaca mulatta). Endocrinology 153, 1887-1897.
Guimiot, F., Chevrier, L., Dreux, S., Chevenne, D., Caraty, A., Delezoide, A. L., et al. (2012). Negative fetal FSH/LH regulation in late pregnancy is associated with declined kisspeptin/KISS1R expression in the tuberal hypothalamus. J. Clin. Endocrinol. Metab. 97, E2221-E2229.
Herbison, A. E., de Tassigny, X., Doran, J., and Colledge, W. H. (2010). Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons. Endocrinology 151, 312-321.
Hiney, J. K., Srivastava, V. K., Pine, M. D., and Les Dees, W. (2009). Insulin-like growth factor-I activates KiSS-1 gene expression in the brain of the prepubertal female rat. Endocrinology 150, 376-384.
Homma, T., Sakakibara, M., Yamada, S., Kinoshita, M., Iwata, K., Tomikawa, J., et al. (2009). Significance of neonatal testicular sex steroids to defeminize anteroventral periventricular kisspeptin neurons and the GnRH/LH surge system in male rats. Biol. Reprod. 81, 1216-1225.
Hrabovszky, E., Ciofi, P., Vida, B., Horvath, M. C., Keller, E., Caraty, A., et al. (2010). The kisspeptin system of the human hypothalamus, sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons. Eur. J. Neurosci. 31, 1984-1998.
Hrabovszky, E., Molnár, C. S., Sipos, M. T., Vida, B., Ciofi, P., Borsay, B. A., et al. (2011). Sexual dimorphism of kisspeptin and neurokinin B immunoreactive neurons in the infundibular nucleus of aged men and women. Front. Endocrinol. (Lausanne) 2, 80. doi:10.3389/fendo.2011.00080
Huhtaniemi, I. (1995). Molecular aspects of the ontogeny of the pituitary-gonadal axis. Reprod. Fertil. Dev. 7, 1025-1035.
Iijima, N., Takumi, K., Sawai, N., and Ozawa, H. (2011). An immunohistochemical study on the expressional dynamics of kisspeptin neurons relevant to GnRH neurons using a newly developed anti-kisspeptin antibody. J. Mol. Neurosci. 43, 146-154.
Iwasa, T., Matsuzaki, T., Murakami, M., Kinouchi, R., Gereltsetseg, G., Fujisawa, S., et al. (2010a). Sensitivities of mRNA expression levels of Kiss1 and its receptor, Kiss1r, to nutritional status are changed during the developmental period in female rats. J. Endocrinol. 207, 195-202.
Iwasa, T., Matsuzaki, T., Murakami, M., Fujisawa, S., Kinouchi, R., Gereltsetseg, G., et al. (2010b). Effects of intrauterine undernutrition on hypothalamic Kiss1 expression and the timing of puberty in female rats. J. Physiol. (Lond.) 588, 821-829.
Kauffman, A. S., Navarro, V. M., Kim, J., Clifton, D. K., and Steiner, R. A. (2009). Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice, implications for the timing of puberty. Am. J. Physiol. Endocrinol. Metab. 297, E1212-E1221.
Kauffman, A. S., Park, J. H., McPhie-Lalmansingh, A. A., Gottsch, M. L., Bodo, C., Hohmann, J. G., et al. (2007a). The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior. J. Neurosci. 127, 8826-8835.
Kauffman, A. S., Gottsch, M. L., Roa, J., Byquist, A. C., Crown, A., Clifton, D. K., et al. (2007b). Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology 148, 1774-1783.
Keen, K. L., Wegner, F. H., Bloom, S. R., Ghatei, M. A., and Terasawa, E. (2008). An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo. Endocrinology 149, 4151-4157.
Kermath, B. A., and Gore, A. C. (2012). Neuroendocrine control of the transition to reproductive senescence, lessons learned from the female rodent model. Neuroendocrinology 96, 1-12.
Kim, W., Jessen, H. M., Auger, A. P., and Terasawa, E. (2009). Postmenopausal increase in KiSS-1, GPR54, and luteinizing hormone releasing hormone (LHRH-1) mRNA in the basal hypothalamus of female rhesus monkeys. Peptides 30, 103-110.
Kinsey-Jones, J. S., Li, X. F., Knox, A. M., Wilkinson, E. S., Zhu, X. L., Chaudhary, A. A., et al. (2009). Down-regulation of hypothalamic kisspeptin and its receptor, Kiss1r, mRNA expression is associated with stress-induced suppression of luteinising hormone secretion in the female rat. J. Neuroendocrinol. 21, 20-29.
Knox, A. M., Li, X. F., Kinsey-Jones, J. S., Wilkinson, E. S., Wu, X. Q., Cheng, Y. S., et al. (2009). Neonatal lipopolysaccharide exposure delays puberty and alters hypothalamic Kiss1 and Kiss1r mRNA expression in the female rat. J. Neuroendocrinol. 21, 683-689.
Kurian, J. R., Keen, K. L., Guerriero, K. A., and Terasawa, E. (2012). Tonic control of kisspeptin release in prepubertal monkeys, implications to the mechanism of puberty onset. Endocrinology 153, 3331-3336.
Lapatto, R., Pallais, J. C., Zhang, D., Chan, Y. M., Mahan, A., Cerrato, F., et al. (2007). Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice. Endocrinology 148, 4927-4936.
Lederman, M. A., Lebesgue, D., Gonzalez, V. V., Shu, J., Merhi, Z. O., Etgen, A. M., et al. (2010). Age-related LH surge dysfunction correlates with reduced responsiveness of hypothalamic anteroventral periventricular nucleus kisspeptin neurons to oestradiol positive feedback in middle-aged rats. Neuropharmacology 58, 314-320.
Lee, D. K., Nguyen, T., O'Neill, G. P., Cheng, R., Liu, Y., Howard, A. D., et al. (1999). Discovery of a receptor related to the galanin receptors. FEBS Lett. 446, 103- 107.
Lee, J. H., Miele, M. E., Hicks, D. J., Phillips, K. K., Trent, J. M., Weissman, B. E., et al. (1996). KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J. Natl. Cancer Inst. 88, 1731-1737.
Lehman, M. N., Merkley, C. M., Coolen, L. M., and Goodman, R. L. (2010). Anatomy of the kisspeptin neural network in mammals. Brain Res. 1364, 90-102.
Li, F. X., Lin, Y. S., Kinsey-Jones, J. S., and O'Byrne, K. T. (2012). High-fat diet increases LH pulse frequency and kisspeptin-neurokinin B expression in pubertyadvanced female rats. Endocrinology 153, 4422-4431.
Li, Q., Rao, A., Pereira, A., Clarke, I. J., and Smith, J. T. (2011). Kisspeptin cells in the ovine arcuate nucleus express prolactin receptor but not melatonin receptor. J. Neuroendocrinol. 23, 871-882.
Losa, S. M., Todd, K. L., Sullivan, A. W., Cao, J., Mickens, J. A., and Patisaul, H. B. (2011). Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat. Reprod. Toxicol. 31, 280-289.
Losa-Ward, S. M., Todd, K. L., McCaffrey, K. A., Tsutsui, K., and Patisaul, H. B. (2012). Disrupted organization of RFamide pathways in the hypothalamus is associated with advanced puberty in female rats neonatally exposed to bisphenol A. Biol. Reprod. 87, 28.
Luan, X., Yu, H., Wei, X., Zhou, Y., Wang, W., Li, P., et al. (2007a). GPR54 polymorphisms in Chinese girls with central precocious puberty. Neuroendocrinology 86, 77-83.
Luan, X., Zhou, Y., Wang, W., Yu, H., Li, P., Gan, X., et al. (2007b). Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls. Eur. J. Endocrinol. 157, 113-118.
Matsui, H., Takatsu, Y., Kumano, S., Matsumoto, H., and Ohtaki, T. (2004). Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem. Biophys. Res. Commun. 320, 383-388.
Matwijiw, I., and Faiman, C. (1987). Control of gonadotropin secretion in the ovine fetus, the effects of a specific gonadotropin-releasing hormone antagonist on pulsatile luteinizing hormone secretion. Endocrinology 121, 347-351.
Mayer, C., Acosta-Martinez, M., Dubois, S. L., Wolfe, A., Radovick, S., Boehm, U., et al. (2010). Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons. Proc. Natl. Acad. Sci. U.S.A. 107, 22693-22698.
Mayer, C., and Boehm, U. (2011). Female reproductive maturation in the absence of kisspeptin/GPR54 signaling. Nat. Neurosci. 14, 704-710.
Messager, S., Chatzidaki, E. E., Ma, D., Hendrick, A. G., Zahn, D., Dixon, J., et al. (2005). Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc. Natl. Acad. Sci. U.S.A. 102, 1761-1766.
Michael, S. D., Kaplan, S. B., and MacMillan, B. T. (1980) Peripheral plasma concentrations of LH, FSH, prolactin and GH from birth to puberty in male and female mice. J. Reprod. Fertil. 59, 217-222.
Mueller, J. K., Dietzel, A., Lomniczi, A., Loche, A., Tefs, K., Kiess, W., et al. (2011). Transcriptional regulation of the human KiSS1 gene. Mol. Cell. Endocrinol. 342, 8 -19.
Navarro, V. M. (2012). New insights into the control of pulsatile GnRH release, the role of Kiss1/neurokinin B neurons. Front. Endocrinol. (Lausanne) 3, 48. doi:10.3389/fendo.2012.00048
Navarro, V. M., Castellano, J. M., McConkey, S. M., Pineda, R., Ruiz-Pino, F., Pinilla, L., et al. (2011). Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am. J. Physiol. Endocrinol. Metab. 300, E202-E210.
Navarro, V. M., Fernández-Fernández, R., Castellano, J. M., Roa, J., Mayen, A., Barreiro, M. L., et al. (2004a). Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. J. Physiol. (Lond.) 561, 379-386.
Navarro, V. M., Castellano, J. M., Fernández-Fernández, R., Barreiro, M. L., Roa, J., Sanchez-Criado, J. E., et al. (2004b). Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 145, 4565-4574.
Navarro, V. M., Ruiz-Pino, F., Sánchez-Garrido, M. A., García-Galiano, D., Hobbs, S. J., Manfredi-Lozano, M., et al. (2012). Role of neurokinin B in the control of female puberty and its modulation by metabolic status. J. Neurosci. 15, 2388-2397.
Navarro, V. M., Sánchez-Garrido, M. A., Castellano, J. M., Roa, J., García-Galiano, D., Pineda, R., et al. (2009). Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation. Endocrinology 150, 2359-2367.
Nestor, C. C., Briscoe, A. M., Davis, S. M., Valent, M., Goodman, R. L., and Hileman, S. M. (2012). Evidence of a role for kisspeptin and neurokinin B in puberty of female sheep. Endocrinology 153, 2756-2765.
Nimri, R., Lebenthal, Y., Lazar, L., Chevrier, L., Phillip, M., Bar, M., et al. (2011). A novel loss-of-function mutation in GPR54/KISS1R leads to hypogonadotropic hypogonadism in a highly consanguineous family. J. Clin. Endocrinol. Metab. 96, E536-E545.
Oakley, A. E., Clifton, D. K., and Steiner, R. A. (2009). Kisspeptin signaling in the brain. Endocr. Rev. 30, 713-743.
Ohtaki, T., Shintani, Y., Honda, S., Matsumoto, H., Hori, A., Kanehashi, K., et al. (2001). Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-proteincoupled receptor. Nature 411, 613-617.
Ojeda, S. R., Dubay, C., Lomniczi, A., Kaidar, G., Matagne, V., Sandau, U. S., et al. (2010). Gene networks and the neuroendocrine regulation of puberty. Mol. Cell. Endocrinol. 324, 3-11.
Panzica, G. C., Bo, E., Martini, M. A., Miceli, D., Mura, E., Viglietti-Panzica, C., et al. (2011). Neuropeptides and enzymes are targets for the action of endocrine disrupting chemicals in the vertebrate brain. J. Toxicol. Environ. Health B Crit. Rev. 14, 449-472.
Patisaul, H. B., Losa-Ward, S. M., Todd, K. L., McCaffrey, K. A., and Mickens, J. A. (2012). Influence of ER??. selective agonism during the neonatal period on the sexual differentiation of the rat hypothalamic-pituitary-gonadal (HPG) axis. Biol. Sex Differ. 3, 2.
Patisaul, H. B., Todd, K. L., Mickens, J. A., and Adewale, H. B. (2009). Impact of neonatal exposure to the ERalpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats. Neurotoxicology 30, 350-357.
Paxinos, G., and Ashwell, K. W. S. (eds). (2008). Atlas of the Developing Rat Nervous System, 3rd Edn. San Diego, CA, Academic Press.
Pielecka-Fortuna, J., and Moenter, S. M. (2010). Kisspeptin increases gamma-aminobutyric acidergic and glutamatergic transmission directly to gonadotropinreleasing hormone neurons in an estradiol-dependent manner. Endocrinology 151, 291-300.
Pineda, R., Garcia-Galiano, D., Roseweir, A., Romero, M., Sanchez-Garrido, M. A., Ruiz-Pino, F., et al. (2010). Critical roles of kisspeptins in female puberty and preovulatory gonadotropin surges as revealed by a novel antagonist. Endocrinology 151, 722-730.
Poling, M. C., and Kauffman, A. S. (2012). Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology 149, 4151-4157.
Poling, M. C., and Kauffman, A. S. (2013). Organizational and activational effects of sex steroids on kisspeptin neuron development. Front. Neuroendocrinol. 34, 3- 17.
Quennell, J. H., Howell, C. S., Roa, J., Augustine, R. A., Grattan, D. R., and Anderson, G. M. (2011). Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology 152, 1541-1550.
Ramaswamy, S., Seminara, S. B., and Plant, T. M. (2011). Evidence from the agonadal juvenile male rhesus monkey (Macaca mulatta) for the view that the action of neurokinin B to trigger gonadotropin-releasing hormone release is upstream from the kisspeptin receptor. Neuroendocrinology 94, 237-245.
Redmond, J. S., Macedo, G. G., Velez, I. C., Caraty, A., Williams, G. L., and Amstalden, M. (2011a). Kisspeptin activates the hypothalamic-adenohypophyseal-gonadal axis in prepubertal ewe lambs. Reproduction 141, 541-548.
Redmond, J. S., Baez-Sandoval, G. M., Spell, K. M., Spencer, T. E., Lents, C. A., Williams, G. L., et al. (2011b). Developmental changes in hypothalamic Kiss1 expression during activation of the pulsatile release of luteinising hormone in maturing ewe lambs. J. Neuroendocrinol. 23, 815-822.
Revel, F. G., Saboureau, M., Masson-Pévet, M., Pévet, P., Mikkelsen, J. D., and Simonneaux, V. (2006). Kisspeptin mediates the photoperiodic control of reproduction in hamsters. Curr. Biol. 16, 1730-1735.
Rizwan, M. Z., Poling, M. C., Corr, M., Cornes, P. A., Augustine, R. A., Quennell, J. H., et al. (2012). RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology 153, 3770-3779.
Roa, J., Garcia-Galiano, D., Varela, L., Sánchez-Garrido, M. A., Pineda, R., Castellano, J. M., et al. (2009). The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinology 150, 5016-5026.
Rometo, A. M., Krajewski, S. J., Voytko, M. L., and Rance, N. E. (2007). Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J. Clin. Endocrinol. Metab. 92, 2744-2750.
Roseweir, A. K., Kauffman, A. S., Smith, J. T., Guerriero, K. A., Morgan, K., Pielecka-Fortuna, J., et al. (2009). Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J. Neurosci. 29, 3920-3929.
Scarbrough, K., and Wise, P. M. (1990). Age-related changes in pulsatile luteinizing hormone release precede the transition to estrous acyclicity and depend upon estrous cycle history. Endocrinology 126, 884-890.
Semaan, S. J., Dhamija, S., Kim, J., Ku, E. C., and Kauffman, A. S. (2012). Assessment of epigenetic contributions to sexually-dimorphic kiss1 expression in the anteroventral periventricular nucleus of mice. Endocrinology 153, 1875-1886.
Semaan, S. J., Murray, E. K., Poling, M. C., Dhamija, S., Forger, N. G., and Kauffman, A. S. (2010). BAX-dependent and BAX-independent regulation of Kiss1 neuron development in mice. Endocrinology 151, 5807-5817.
Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S. Jr., Shagoury, J. K., et al. (2003). The GPR54 gene as a regulator of puberty. N. Engl. J. Med. 349, 1614-1627.
Shahab, M., Mastronardi, C., Seminara, S. B., Crowley, W. F., Ojeda, S. R., and Plant, T. M. (2005). Increased hypothalamic GPR54 signaling, a potential mechanism for initiation of puberty in primates. Proc. Natl. Acad. Sci. U.S.A. 102, 2129-2134.
Silveira, L. G., Noel, S. D., Silveira-Neto, A. P., Abreu, A. P., Brito, V. N., Santos, M. G., et al. (2010). Mutations of the KISS1 gene in disorders of puberty. Clin. Endocrinol. Metab. 95, 2276-2280.
Smith, J. T., Clay, C. M., Caraty, A., and Clarke, I. J. (2007). KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. Endocrinology 148, 1150-1157.
Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., and Steiner, R. A. (2005). Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology 146, 3686-3692.
Smith, J. T., Popa, S. M., Clifton, D. K., Hoffman, G. E., and Steiner, R. A. (2006a). Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J. Neurosci. 26, 6687-6694.
Smith, J. T., Acohido, B. V., Clifton, D. K., and Steiner, R. A. (2006b). KiSS-1 neurones are direct targets for leptin in the ob/ob mouse. J. Neuroendocrinol. 18, 298- 303.
Szymanski, L., and Bakker, J. (2012). Aromatase knockout mice show normal steroid-induced activation of gonadotrophin-releasing hormone neurones and luteinising hormone surges with a reduced population of kisspeptin neurones in the rostral hypothalamus. J. Neuroendocrinol. 24, 1222-1233.
Takase, K., Uenoyama, Y., Inoue, N., Matsui, H., Yamada, S., Shimizu, M., et al. (2009). Possible role of oestrogen in pubertal increase of Kiss1/kisspeptin expression in discrete hypothalamic areas of female rats. J. Neuroendocrinol. 21, 527-537.
Takumi, K., Iijima, N., Iwata, K., Higo, S., and Ozawa, H. (2012a). The effects of gonadal steroid manipulation on the expression of Kiss1 mRNA in rat arcuate nucleus during postnatal development. J Physiol Sci 62, 453-460.
Takumi, K., Iijima, N., Higo, S., and Ozawa, H. (2012b). Immunohistochemical analysis of the colocalization of corticotropin-releasing hormone receptor and glucocorticoid receptor in kisspeptin neurons in the hypothalamus of female rats. Neurosci. Lett. 2012 531, 40-45.
Takumi, K., Iijima, N., and Ozawa, H. (2011). Developmental changes in the expression of kisspeptin mRNA in rat hypothalamus. J. Mol. Neurosci. 43, 138-145.
Tata, B. K., Chung, W. C., Brooks, L. R., Kavanaugh, S. I., and Tsai, P. S. (2012). Fibroblast growth factor signaling deficiencies impact female reproduction and kisspeptin neurons in mice. Biol. Reprod. 86, 119.
Teles, M. G., Bianco, S. D., Brito, V. N., Trarbach, E. B., Kuohung, W., Xu, S., et al. (2008). A GPR54-activating mutation in a patient with central precocious puberty. N. Engl. J. Med. 358, 709-715.
Todd, B. J., Fraley, G. S., Peck, A. C., Schwartz, G. J., and Etgen, A. M. (2007). Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats. Biol. Reprod. 77, 492-503.
Topaloglu, A. K., Reimann, F., Guclu, M., Yalin, A. S., Kotan, L. D., Porter, K. M., et al. (2009). TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. Nat. Genet. 41, 354-358.
Topaloglu, A. K., Tello, J. A., Kotan, L. D., Ozbek, M. N., Yilmaz, M. B., Erdogan, S., et al. (2012). Inactivating KISS1 mutation and hypogonadotropic hypogonadism. N. Engl. J. Med. 366, 629-635.
Ugrumov, M. V., Ivanova, I. P., Mitskevich, M. S., Liposits, Z., Sétáló, G., and Flerkó, B. (1985). Axovascular relationships in developing median eminence of perinatal rats with special reference to luteinizing hormone-releasing hormone projections. Neuroscience 16, 897-906.
Vida, B., Deli, L., Hrabovszky, E., Kalamatianos, T., Caraty, A., Coen, C. W., et al. (2010). Evidence for suprachiasmatic vasopressin neurones innervating kisspeptin neurones in the rostral periventricular area of the mouse brain, regulation by oestrogen. J. Neuroendocrinol. 22, 1032-1039.
Wahab, F., Quinton, R., and Seminara, S. B. (2011). The kisspeptin signaling pathway and its role in human isolated GnRH deficiency. Mol. Cell. Endocrinol. 346, 29 -36.
Witham, E. A., Meadows, J. D., Shojaei, S., Kauffman, A. S., and Mellon, P. L. (2012). Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology 153, 4522-4532.
Wu, M., Dumalska, I., Morozova, E., van den Pol, A., and Alreja, M. (2009). Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction. Proc. Natl. Acad. Sci. U.S.A. 106, 17217-17222.
Xi, W., Lee, C. K., Yeung, W. S., Giesy, J. P., Wong, M. H., Zhang, X., et al. (2011). Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice. Reprod. Toxicol. 31, 409-417.