Biodegradable microparticles loaded with thrombin receptor agonist peptide for gastric ulcer treatment in rats

Markvicheva, E.; Stashevskaya, K.; Strukova, S.; Prudchenko, I.; Rusanova, A.; Makarova, A.; Vasilieva, T.; Bespalova, J.; Grandfils, Christian

doi:10.1016/S1773-2247(06)50057-7

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Article (Scientific journals)

Biodegradable microparticles loaded with thrombin receptor agonist peptide for gastric ulcer treatment in rats

Markvicheva, E.; Stashevskaya, K.; Strukova, S. et al.

2006 • In Journal of Drug Delivery Science and Technology, 16 (4, JUL-AUG), p. 321-325

Peer reviewed

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https://hdl.handle.net/2268/144638

DOI
10.1016/S1773-2247(06)50057-7

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Keywords :

controlled release; PLGA microparticles; entrapped TRAP-6; PAR-I agonist; ulcer; mucosa; tissue repair

Abstract :

[en] The aim of the current paper was to elaborate an immobilization method of thrombin receptor agonist peptide (TRAP-6) in biodegradable biocompatible poly(d,l)-lactide-co-glycolide (PLGA) inicroparticles and to demonstrate the effect of the entrapped peptide for tissue repair, namely,for a gastric ulcer treatment in rats. TRAP-6 was entrapped in polymer using w/o/w double emulsion-evaporation technique. The morphology of empty and TRAP-6 loaded microparticles was evaluated by light and scanning electron microscopy (SEM). In vitro release kinetics profile of TRAP-6 from microparticles was studied by HPLC. To investigate gastric mucosal protection effect in vivo, TRAP-6-loaded microparticles were administered in a rat stomach after a previous mucosal injury (a gastric ulcer). Microparticles with entrapped TRAP-6 were found to reduce both an inflammation and proliferation phases of wound healing, and thus accelerated tissue repair in rats.

Research center :

CEIB - Centre Interfacultaire des Biomatériaux - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Markvicheva, E.

Stashevskaya, K.

Strukova, S.

Prudchenko, I.

Rusanova, A.

Makarova, A.

Vasilieva, T.

Bespalova, J.

Grandfils, Christian ; Université de Liège - ULiège > Biochimie et physiologie générale

Language :

English

Title :

Biodegradable microparticles loaded with thrombin receptor agonist peptide for gastric ulcer treatment in rats

Publication date :

2006

Journal title :

Journal of Drug Delivery Science and Technology

ISSN :

1773-2247

Publisher :

Editions Sante, Paris, France

Volume :

Issue :

4, JUL-AUG

Pages :

321-325

Peer reviewed :

Peer reviewed

Name of the research project :

Programme de travail Région Wallonne/Fédération de Russie 2001- 2002, Art. 3. , Projet de coopération n°3, en collaboration avec : Shemyakin Institute Bioorganic Chemistry, Moscow, Professor Vitali P. Zubov et du Dr. Elena Markvicheva

Funders :

WBI - Wallonie-Bruxelles International [BE]

Available on ORBi :

since 12 March 2013

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