Biodegradable microparticles loaded with thrombin receptor agonist peptide for gastric ulcer treatment in rats

Markvicheva, E.; Stashevskaya, K.; Strukova, S.; Prudchenko, I.; Rusanova, A.; Makarova, A.; Vasilieva, T.; Bespalova, J.; Grandfils, Christian

doi:10.1016/S1773-2247(06)50057-7

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Article (Scientific journals)

Biodegradable microparticles loaded with thrombin receptor agonist peptide for gastric ulcer treatment in rats

Markvicheva, E.; Stashevskaya, K.; Strukova, S. et al.

2006 • In Journal of Drug Delivery Science and Technology, 16 (4, JUL-AUG), p. 321-325

Peer reviewed

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https://hdl.handle.net/2268/144638

DOI
10.1016/S1773-2247(06)50057-7

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Keywords :

controlled release; PLGA microparticles; entrapped TRAP-6; PAR-I agonist; ulcer; mucosa; tissue repair

Abstract :

[en] The aim of the current paper was to elaborate an immobilization method of thrombin receptor agonist peptide (TRAP-6) in biodegradable biocompatible poly(d,l)-lactide-co-glycolide (PLGA) inicroparticles and to demonstrate the effect of the entrapped peptide for tissue repair, namely,for a gastric ulcer treatment in rats. TRAP-6 was entrapped in polymer using w/o/w double emulsion-evaporation technique. The morphology of empty and TRAP-6 loaded microparticles was evaluated by light and scanning electron microscopy (SEM). In vitro release kinetics profile of TRAP-6 from microparticles was studied by HPLC. To investigate gastric mucosal protection effect in vivo, TRAP-6-loaded microparticles were administered in a rat stomach after a previous mucosal injury (a gastric ulcer). Microparticles with entrapped TRAP-6 were found to reduce both an inflammation and proliferation phases of wound healing, and thus accelerated tissue repair in rats.

Research Center/Unit :

CEIB - Centre Interfacultaire des Biomatériaux - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Markvicheva, E.

Stashevskaya, K.

Strukova, S.

Prudchenko, I.

Rusanova, A.

Makarova, A.

Vasilieva, T.

Bespalova, J.

Grandfils, Christian ; Université de Liège - ULiège > Biochimie et physiologie générale

Language :

English

Title :

Biodegradable microparticles loaded with thrombin receptor agonist peptide for gastric ulcer treatment in rats

Publication date :

2006

Journal title :

Journal of Drug Delivery Science and Technology

ISSN :

1773-2247

Publisher :

Editions Sante, Paris, France

Volume :

Issue :

4, JUL-AUG

Pages :

321-325

Peer reviewed :

Peer reviewed

Name of the research project :

Programme de travail Région Wallonne/Fédération de Russie 2001- 2002, Art. 3. , Projet de coopération n°3, en collaboration avec : Shemyakin Institute Bioorganic Chemistry, Moscow, Professor Vitali P. Zubov et du Dr. Elena Markvicheva

Funders :

WBI - Wallonie-Bruxelles International

Available on ORBi :

since 12 March 2013

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STRUKOVA, S.M., DUGINA, T.N., CHISTOV, I.V., LANGE, M.A., MARKVICHEVA, E.A., KUPTSOVA, S.V., ZUBOV, V.P., GLUSA, E. - Immobilized Thrombin Receptor Agonist Peptide Accelerates Wound Healing in Mice. - Clin. Appl. Thromb. Hemost., 7, 325-329, 2001.
DHANARAJU, M.D., JAYAKUMAR, R., VAMSADHARA, C. - Influence of manufacturing parameters on development of contraceptive steroid loaded injectable microspheres. - Chem. Pharm. Bull. Tokyo, 52 (8), 976-979, 2004.
HUSSAIN, M., BEALE, G., HUDHES, M., AKHTAR, S. - Co-delivery of an antisense oligonucleotide and 5-fluorouracil using sustained release poly (lactide-co-glycolide) microsphere formulations for potential combination therapy in cancer. - Int. J. Pharm., 234 (1-2), 129-38, 2002.
KUMANOHOSO, T., NATSUGOE, S., SHIMADA, M., AIKOU, T. - Enhancement of therapeutic efficacy of bleomycin by incorporation into biodegradable poly-d,l-lactic acid. Cancer Chemother. Pharmacol., 40 (2), 112-6, 1997.
LUBY, T.M., COLE, G., BAKER, L., KORNHER, S., RAMSTEDT, U., HEDLEY, M.L. - Repeated immunization with plasmid DNA formulated in poly(lactide-co- glycolide) microparticles is well tolerated and stimulates durable T cell response to the tumor-associated antigen cytochrome P450 1B1. - Clin. Immunol., 112, 45-53, 2004.
CLARK, S.L., CROWLEY, A.J., SCHMIDT, P.G., DONOGHUE, A.R., PICHE, C.A. - Long-term delivery of ivermectin by use of poly(D,L-lactic-co-glycolic)acid microparticles in dogs. - Am. J. Vet. Res., 65 (6), 752-757, 2004.
MIKHAILOVA, A.G., LIKHAREVA, V.V., VASKOVSKI, B.V., GARANIN, S.K., ONOPRIENKO, L.V., PRUDCHENKO, I.A., CHIKIN L.D., RUMSH, L.D. 2004. - Study of secondary specificity of enteropeptidase in comparison with trypsin, Biochemistry (Moscow), 69/8, 909-917, 2004.
OKABE, S., ROTH, J.L., PFEIFFER, C.J. - A method for experimental, penetrating gastric and duodenal ulcers in rats. Observations on normal healing. - Am. J. Dig. Dis., 3, 277-284, 1971.
NIHANT, N., SHUGENS, Ch., GRANFILS, Ch., JOROME, R., TEYSSIE P. - Polylactide microparticles prepared by double emulsion/evaporation technique. I. Effect of primary emulsion stability. - Pharm. Res., 11/10, 1479-1484, 1994.
NIHANT, N., SCHUGENS Ch, GRANDFILS, Ch., JEROME, R., TEYSSIE P. - Polylactide microparticles prepared by double emulsion-evaporation. II. Effect of poly(lactide-co-glycolide) composition on the stability of the primary and secondary emulsions. J. Colloid Interfacial Sci., 173, 55-65, 1995.
WISCHKE, C., LORENZEN, D., ZIMMERMANN, J., BORCHERT, H.H. - Preparation of protein loaded poly(d,l-lactide-co-glycolide) microparticles for the antigen delivery to dendritic cells using a static micromixer. - Eur. J. Pharm. Biopharm., Nov. 7, 2005 (Epub ahead of print)
HINDS, K.D., CAMPBELL, K.M., HOLLAND, K.M., LEWIS, D.H., PICHE, C.A., SCHMIDT, P.G. - PEGylated insulin in PLGA microparticles. In vivo and in vitro analysis - J. Control. Release, 104 (3), 447-460, 2005.
MARKVICHEVA, E., DUGINA, T., GRANDFILS, Ch., LANGE M., STASHEVSKAYA K., VASILIEVA T, RUMSH L., STRUKOVA S., et al. - Application of bioencapsulated proteinases and peptides for wound healing, Chapter 12 - In: Advanced Biomaterials for Medical Applications, Series II Mathematics, Physics and Chemistry, Thomas D.W. (Ed.), Kluwer Academic Publishers, Dordrecht-Boston- London, 2004, pp. 165-176.
DUGINA, T.N., KISELEVA, E.V., LANGE, M.A., VASILIEVA T.V., GRANDFILS Ch., MARKVICHEVA E.A., BESPALOVA E.D., PALKEEVA M.E., STRUKOVA S.M. - Effect of synthetic peptide-thrombin receptor agonist peptide-encapsulated in poly(lactide-co-glycolide) microparticles on wound healing in mice - Bull. Exp. Biol. Med., 138 (11), 523-527, 2004 (in Russian).
KAWABATA, A., - Gastrointestinal functions of proteinase-activated receptors. - Life Sci., 74 (2-3), 247-254, 2003.
KAWABATA, A., NISHIKAWA, H., SAITOH, H., NAKAYA, Y., HITAMATSU, K., KUBO, S., NISHIDA, M., KAWAO, N., KURODA, R., SEKIGUCHI, F., KINOSHITA, M., KAKEHI, K., ARIZONO, N., YAMAGISHI, H., KAWAI, K. - A protective role of protease-activated receptor 1 in rat gastric mucosa - Gastroenterology, 126 (1), 208-19, 2004.