Reference : Lactase Insufficiency Revisited
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/144624
Lactase Insufficiency Revisited
English
Forget, P []
Lombet, Jacques [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > > NÉPHROLOGIE PÉDIATRIQUE > >]
Grandfils, Christian mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Dandrifosse, Guy mailto [Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Geubelle, Fernand []
1985
Journal of Pediatric Gastroenterology and Nutrition
Lippincott Williams & Wilkins
4
868-872
Yes (verified by ORBi)
International
0277-2116
1536-4801
Philadelphia
PA
[en] Lactase ; Small bowel ; Lactose breath hydrogen test
[en] The definition of "insufficient" small bowel lactase activity varies greatly among authors. The present study is aimed at redefining lactase insufficiency by comparing intestinal lactase activity and results of the lactose breath hydrogen test. Primary "insufficient" lactase activity was considered to be present when a child with a normal small bowel histology showed lactose malabsorption as measured by the lactose breath hydrogen test. The lactase activity of 22 "normal" children ranged from 0.77 to 4.57 U/g wet weight, while five children showed primary lactase insufficiency as defined above. Small bowel lactase activity in the latter patients was < 0.74 U/g wet weight. Sucrase and maltase activities were similar in both groups of patients. We conclude that children with a normal small bowel histology should be considered to have primary lactase insufficiency when small bowel lactase activity is below 0.75 U/g wet weight.
Department of Pediatrics and Department of General and Comparative Biochemistry
http://hdl.handle.net/2268/144624

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