Reference : Action potential of the median giant fibre of the earthworm, lumbricus terrestris, as...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Action potential of the median giant fibre of the earthworm, lumbricus terrestris, as a pharmacological test of the radio-labelled TTX-derivatives activity
Daemers-Lambert, Claire [Université de Liège - ULiège > Océanologie > > >]
Grandfils, Christian mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Comparative Biochemistry and Physiology. C, Comparative Pharmacology
Pergamon Press
Yes (verified by ORBi)
United Kingdom
[en] Lumbricus Terrestris ; TTX
[en] The isolated median giant fibre action potential from the earthworm nerve cord was recorded in a double sucrose-gap apparatus used in current-clamp configuration. [3H]Lysine-TTX was synthesized and its inhibitory effect on the spike area was measured. Its activity is very similar to that of TTX. The dose-response curve obtained with superthreshold stimuli is shown to be the right-hand side of the Kd/(Kd+[TTX]) relation. A 3.9 nM Kd is calculated which agrees with the known values for the frog Ranvier node.
Laboratoire d'Océanologie et Laboratoire de Biochimie Générale et Comparée

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1988 Daemers-Lambert n°19.PDFPublisher postprint5.07 MBRequest copy

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