Reference : Macromolecular engineering of lactone-based (co)polymers for biomedical applications
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Macromolecular engineering of lactone-based (co)polymers for biomedical applications
Dubois, Philippe mailto [Université de Liège - ULiège > Services généraux (Faculté des sciences) > Relations académiques et scientifiques (Sciences) >]
Grandfils, Christian mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Jérôme, Robert mailto [Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences) >]
Teyssié, Ph []
Polymer Chemistry
Royal Society Chemistry
32 (1)
Yes (verified by ORBi)
United Kingdom
[en] PCL ; lactone
[en] Ring-opening polymerization of epsilon-caprolactone and lactides by aluminum alkoxides allows aliphatic polyesters to be tailored at will and fitted to requirements for biomedical applications, particularly for controlled drug delivery systems. Variation in molecular weight controls the effective life time of microspheres or implants in vivo. Block copolymerization leads to microphase separated materials and opportunity to modify the overall release kinetics and to get, for instance, a zero-order. Macromonomers and dimacromonomers are ideal precursors for physically and chemically stabilized hydrogels, respectively. Dimacromonomers can actually generate amphiphilic networks.
University of Liege, Laboratory of Macromolecular Chemistry & Organic Catalysis

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1991 Dubois n°25.PDFPublisher postprint2.54 MBRequest copy

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