Reference : Synthesis and Inverse Emulsion Polymerization of Aminated Acrylamidodextran
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Synthesis and Inverse Emulsion Polymerization of Aminated Acrylamidodextran
Daubresse, Catherine []
Grandfils, Christian mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Jérôme, Robert mailto [Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences) >]
Teyssié, Ph []
Goethals, P []
Schacht, E []
Journal of Pharmacy and Pharmacology
Pharmaceutical Press
Yes (verified by ORBi)
United Kingdom
[en] Inverse emulsion ; polymerization ; acrylamidodextran
[en] A chemically modified form of dextran was prepared; having a polymerizable moiety (acrylamide) and a reactive functional group (primary amine). Dextran was activated with 4-nitrophenylchloroformate (24 mol per polysaccharide, 9,8 mol per 100 glucose residues); 9,8% glucose residues were converted to aliphatic carbonates and 5,2% were converted to cyclic carbonates. The activated dextran was coupled with trityldiaminoethane (8 mol per 100 glucose residues), reactivated with 4-nitrophenylchloroformate, then coupled with acryloamidodiaminohexane (6,8 mol per 100 glucose residues). The trityl group was removed by hydrolysis with trifluoroacetic acid to yield the required aminated acryloamidodextran. The modified dextran was shown to be polymerizable by inverse emulsion polymerization. Submicron particules were successfully prepared, containing functional amine groups suitable for preparing drug conjugates or for modifying the surface properties of thisbiomaterial.
Centre d'Etudes et de Recherches sur les Macromolécules, University of Liege & Laboratory of Organic Chemistry, Gent

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