Microencapsulation by Coacervation of Poly(lactide-co-glycolide)-II:Encapsulation of a Dispersed Aqueous Phase

Nihant, Nicole; Stassen, S; Grandfils, Christian; Jérôme, Robert; Teyssié, Ph

Reference : Microencapsulation by Coacervation of Poly(lactide-co-glycolide)-II:Encapsulation of ...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/144609

Title :	Microencapsulation by Coacervation of Poly(lactide-co-glycolide)-II:Encapsulation of a Dispersed Aqueous Phase
Language :	English
Author, co-author :	Nihant, Nicole []
	Stassen, S []
	Grandfils, Christian [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
	Jérôme, Robert [Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences) >]
	Teyssié, Ph []
Publication date :	1993
Journal title :	Polymer International
Volume :	32
Pages :	171-176
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0959-8103
e-ISSN :	1097-0126
Keywords :	[en] Microencapsulation ; Coacervation ; Surface tension ; Interfacial ; Tension ; Polylactide ; Polylactide-co-glycolide ; Protein encapsulation
Abstract :	[en] This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This coating process can be divided in three successive steps: phase separation of the coating polymer; adsorption of the coacervate droplets around the drugs phase, and microcapsule solidification. This paper focuses on the physico-chemical analysis of the second step. The knowledge of the interfacial tensions between the three liquid phases allows understanding of the microscopic evolution of the phase separation medium.
Research centres :	Center for Education and Research on Macromolecules (CERM) - University of Liege
Permalink :	http://hdl.handle.net/2268/144609

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