Article (Scientific journals)
Drug Interactions with Normal and TEN Epidermal Keratinocytes.
Paquet, Philippe; Delvenne, Philippe; PIERARD, Gérald
2012In Current Drug Safety, 7 (5), p. 352-6
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Abstract :
[en] Human epidermal keratinocytes (EKs) are metabolically involved in various drug transport mechanisms, as well as in detoxification or activation processes. The overall cell mechanisms of drug metabolization, and more specifically drug processing are reviewed in normal EKs. The overall drug metabolism involves different phases corresponding to the uptake, biotransformation and anti-transport steps. In EKs, both the enzymes and transportassociated proteins are different from those involved in the hepatocyte metabolism. Some cytochrome P450 enzymes and the flavin-containing mono-oxygenases are particularly involved in EKs. Basically, EKs represent key cells likely involved during the initial stage of drug-induced toxic epidermal necrolysis (TEN). Only limited advances have been made so far in this field. Nevertheless, mitigating EKs metabolic disturbances in TEN probably represent a promising specific treatment of the disease.
Disciplines :
Dermatology
Author, co-author :
Paquet, Philippe
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
PIERARD, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Drug Interactions with Normal and TEN Epidermal Keratinocytes.
Publication date :
2012
Journal title :
Current Drug Safety
ISSN :
1574-8863
eISSN :
2212-3911
Publisher :
Bentham Science Publishers, United Arab Emirates
Volume :
7
Issue :
5
Pages :
352-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 March 2013

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