Reference : Diagnostic value of neurotrophin expression in malignant pleural effusions
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/144032
Diagnostic value of neurotrophin expression in malignant pleural effusions
English
DUYSINX, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
PAULUS, Aurore [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire et imagerie oncologique >]
HEINEN, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
NGUYEN DANG, Delphine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
HENKET, Monique mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
CORHAY, Jean-Louis mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Louis, Renaud mailto [Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie >]
2011
Experimental and Therapeutic Medicine
Spandidos Publications
2
5
941-946
Yes (verified by ORBi)
International
1792-0981
1792-1015
Amiens
Greece
[en] Cancer ; Exudate ; Lymphocyte effusion ; Neurotrophin ; Pleural effusion
[en] Neurotrophins (NTs) modulate the growth of human malignancies, including lung cancers. Our prospective study evaluated the accuracy of pleural NTs [nerve growth factor, brain-derived neurotrophic factor (BDNF), neurotrophin 3 (nT3) and 4 (nT4)] levels for differentiating benign from malignant pleural exudates. Levels of NTs were measured by ELISA in 170 patients with non-neutrophilic (<50%) exudative benign or malignant pleurisies diagnosed by pleuroscopy. Fifty-nine benign (9 infections and 50 inflammatory diseases) and 111 malignant (50 extrathoracic tumors, 51 lung cancers and 10 mesotheliomas) pleural exudates were diagnosed by thoracoscopy. Levels of BDNF were significantly higher in malignant than in benign effusions [17 pg/ml (0-367) vs. 8 pg/ml (0-51), p<0.05]. ROC analysis showed an area under the curve of 0.609 (p=0.012; best threshold 44 pg/ml). Pleural BDNF levels were significantly higher in pleural metastasis of pulmonary tumors and in mesothelioma than in pleural benign effusions. Finally, a higher proportion of pleural nT3 was detected in squamous cell lung carcinoma in comparison to that in non-squamous cell lung carcinoma (72.7 vs. 10%, p<0.0001). NTs and particularly BDNF may play a role in the pathogenesis of malignant pleural effusions.
http://hdl.handle.net/2268/144032
10.3892/etm.2011.302
http://www.spandidos-publications.com/etm/2/5

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