Reference : Glycine receptor activation controls interneuron migration by affecting nuclear trans...
Scientific congresses and symposiums : Poster
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Glycine receptor activation controls interneuron migration by affecting nuclear translocation and myosin phosphorylation
Avila Macaya, Ariel Salvatore mailto [Université de Liège - ULiège > > > Form. doc. sc. bioméd. & pharma.]
Nguyen, Laurent mailto [Université de Liège - ULiège > > GIGA - Neurosciences >]
16th EURON PhD meeting - Maastricht University
September 27-28, 2012
[en] Glycine receptor
[en] Previous studies have described the presence of glycine receptor mRNA during early stages of
embryonic cortex development. Here, we have tested the functionality of those receptors in
migratory interneurons and demonstrated their involvement in the control of cell migration. We
suggest a mechanism whereby activation of glycine receptors during tangential migration
activates voltage gated calcium channels and favors influx of calcium that ultimately affect
myosin II activity, a mechanism that fine tune nuclear translocation and thus migration speed.
Researchers ; Students

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