Reference : Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis ...
Scientific journals : Article
Human health sciences : Surgery
http://hdl.handle.net/2268/143444
Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism.
English
Helgadottir, Anna [> >]
Gretarsdottir, Solveig [> >]
Thorleifsson, Gudmar [> >]
Holm, Hilma [> >]
Patel, Riyaz S. [> >]
Gudnason, Thorarinn [> >]
Jones, Gregory T. [> >]
van Rij, Andre M. [> >]
Eapen, Danny J. [> >]
Baas, Annette F. [> >]
Tregouet, David-Alexandre [> >]
Morange, Pierre-Emmanuel [> >]
Emmerich, Joseph [> >]
Lindblad, Bengt [> >]
Gottsater, Anders [> >]
Kiemeny, Lambertus A. [> >]
Lindholt, Jes S. [> >]
SakalihasanN, Natzi mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Ferrell, Robert E. [> >]
Carey, David J. [> >]
Elmore, James R. [> >]
Tsao, Philip S. [> >]
Grarup, Niels [> >]
Jorgensen, Torben [> >]
Witte, Daniel R. [> >]
Hansen, Torben [> >]
Pedersen, Oluf [> >]
Pola, Roberto [> >]
Gaetani, Eleonora [> >]
Magnadottir, Hulda B. [> >]
Wijmenga, Cisca [> >]
Tromp, Gerard [> >]
Ronkainen, Antti [> >]
Ruigrok, Ynte M. [> >]
Blankensteijn, Jan D. [> >]
Mueller, Thomas [> >]
Wells, Philip S. [> >]
Corral, Javier [> >]
Soria, Jose Manuel [> >]
Souto, Juan Carlos [> >]
Peden, John F. [> >]
Jalilzadeh, Shapour [> >]
Mayosi, Bongani M. [> >]
Keavney, Bernard [> >]
Strawbridge, Rona J. [> >]
Sabater-Lleal, Maria [> >]
Gertow, Karl [> >]
Baldassarre, Damiano [> >]
Nyyssonen, Kristiina [> >]
Rauramaa, Rainer [> >]
Smit, Andries J. [> >]
Mannarino, Elmo [> >]
Giral, Philippe [> >]
Tremoli, Elena [> >]
de Faire, Ulf [> >]
Humphries, Steve E. [> >]
Hamsten, Anders [> >]
Haraldsdottir, Vilhelmina [> >]
Olafsson, Isleifur [> >]
Magnusson, Magnus K. [> >]
Samani, Nilesh J. [> >]
Levey, Allan I. [> >]
Markus, Hugh S. [> >]
Kostulas, Konstantinos [> >]
Dichgans, Martin [> >]
Berger, Klaus [> >]
Kuhlenbaumer, Gregor [> >]
Ringelstein, E. Bernd [> >]
Stoll, Monika [> >]
Seedorf, Udo [> >]
Rothwell, Peter M. [> >]
Powell, Janet T. [> >]
Kuivaniemi, Helena [> >]
Onundarson, Pall T. [> >]
Valdimarsson, Einar [> >]
Matthiasson, Stefan E. [> >]
Gudbjartsson, Daniel F. [> >]
Thorgeirsson, Guethmundur [> >]
Quyyumi, Arshed A. [> >]
Watkins, Hugh [> >]
Farrall, Martin [> >]
Thorsteinsdottir, Unnur [> >]
Stefansson, Kari [> >]
2012
Journal of the American College of Cardiology
60
8
722-9
Yes (verified by ORBi)
International
0735-1097
1558-3597
United States
[en] African Americans/genetics ; Age of Onset ; Angiography ; Aortic Aneurysm, Abdominal/genetics ; Apolipoproteins A/genetics ; Atherosclerosis/genetics ; Brain Ischemia/genetics ; Carotid Intima-Media Thickness ; Coronary Artery Disease/genetics ; European Continental Ancestry Group/genetics ; Genetic Predisposition to Disease ; Humans ; Intracranial Aneurysm/genetics ; Linear Models ; Logistic Models ; Myocardial Infarction/genetics ; Odds Ratio ; Peripheral Arterial Disease/genetics ; Polymorphism, Single Nucleotide ; Risk Factors ; Severity of Illness Index ; Stroke/genetics ; Venous Thromboembolism/genetics
[en] OBJECTIVES: The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. BACKGROUND: It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis. METHODS: The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST [Trial of Org 10172 in Acute Stroke Treatment] subtypes) (effective sample size [n(e)] = 9,396); peripheral arterial disease (n(e) = 5,215); abdominal aortic aneurysm (n(e) = 4,572); venous thromboembolism (n(e) = 4,607); intracranial aneurysm (n(e) = 1,328); CAD (n(e) = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). RESULTS: LPA score was associated with ischemic stroke subtype large artery atherosclerosis (odds ratio [OR]: 1.27; p = 6.7 x 10(-4)), peripheral artery disease (OR: 1.47; p = 2.9 x 10(-14)), and abdominal aortic aneurysm (OR: 1.23; p = 6.0 x 10(-5)), but not with the ischemic stroke subtypes cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52). Although the LPA variants were not associated with carotid intima-media thickness, they were associated with the number of obstructed coronary vessels (p = 4.8 x 10(-12)). Furthermore, CAD cases carrying LPA risk variants had increased susceptibility to atherosclerotic manifestations outside of the coronary tree (OR: 1.26; p = 0.0010) and had earlier onset of CAD (-1.58 years/allele; p = 8.2 x 10(-8)) than CAD cases not carrying the risk variants. There was no association of LPA score with venous thromboembolism (OR: 0.97; p = 0.63) or intracranial aneurysm (OR: 0.85; p = 0.15). CONCLUSIONS: LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes.
http://hdl.handle.net/2268/143444
10.1016/j.jacc.2012.01.078
Copyright (c) 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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