Reference : Les maladies complexes: l'importance de la genetique.
Scientific journals : Article
Life sciences : Genetics & genetic processes
Les maladies complexes: l'importance de la genetique.
[en] Complex diseases: the importance of genetics
LIBIOULLE, Cécile mailto [> > > > > >]
BOURS, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Revue Médicale de Liège
Yes (verified by ORBi)
[en] Base Sequence ; Causality ; Disease/etiology/genetics ; Gene-Environment Interaction ; Genetic Diseases, Inborn/epidemiology/etiology ; Genetic Predisposition to Disease/etiology/genetics ; Humans ; Inheritance Patterns/genetics/physiology ; Molecular Sequence Data ; Mutation ; Twins
[en] Complex diseases usually harbour hereditary factors linked with multiple susceptibility genes. The additive effects of genetic and environmental factors are responsible for the pathology. The impact of heredity has been demonstrated through family studies, but also, and mostly, through the study of adopted people and twins. Recently, genome wide association studies (GWAS) allowed the identification of many susceptibility genes for most complex diseases. However, a large part of the heritability is still missing, probably because of insufficient exploration of rare genetic variants and/or epigenetic factors. The ultimate goal of these genetic studies is the definition of an individual risk leading to specific preventive measures (model "predict and prevent"), but this purpose remains very remote for the majority of complex diseases.

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